https://doi.org/10.69107/koomesh-151892

Comparing the Effect of Ondansetron , Dexamethasone and There Combonition in Reducing Postoperative Nausea and Vomiting (PONV) After Hysterectomy, a Single-Blind Randomized Clinical Trial Study

authors:

avatar Mohammadreza Moonesan ORCID 1 , avatar Sanaz Ghenaati ORCID 2 , avatar Elham Saffarieh ORCID 3 , avatar Majid Mirmohammadkhani ORCID 4 , avatar Babak Hosseinzadeh Zoroofchi ORCID 5 , *

Department of Emergency Medicine, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran
General Practitioner, Semnan University of Medical Sciences, Semnan, Iran
Abnormal Uterine Bleeding Research Center, Semnan University of Medical Sciences, Semnan, Iran
Department of Epidemiology and Biostatistics, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran
Department of Anesthesiology, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran
Koomesh: Vol.26, issue 1; e151892
published online: October 15, 2024
article type: Research Article

how to cite: Moonesan M, Ghenaati S, Saffarieh E, Mirmohammadkhani M, Hosseinzadeh Zoroofchi B. Comparing the Effect of Ondansetron , Dexamethasone and There Combonition in Reducing Postoperative Nausea and Vomiting (PONV) After Hysterectomy, a Single-Blind Randomized Clinical Trial Study. koomesh. 2024;26(1):e151892. https://doi.org/10.69107/koomesh-151892.

Abstract

Background:  Hysterectomy is one of the most commonly surgeries in women and has some complications like as other surgeries including nausea and vomiting. Different drugs have been used to reduce this complication.
Objectives:  In this study, the effects of dexamethasone and ondansetron were compared on prevention of nausea and vomiting after hysterectomy.
Methods:  In a randomized, blinded clinical trial study, 76 patients who were candidated for hysterectomy referred to Amirul Mominin Hospital in Semnan in 2016-2018 were enrolled. Patients were randomly assigned to 3 groups. The first group received dexamethasone 16 mg,  the second group received ondansetron 4 mg, and the third group received ondansetron 4 mg plus dexamethasone 16 mg, intravenously. The data collected by a checklist. The incidence of nausea and vomiting was recorded and analyzed in the recovery room, 6 and 24 hours after surgery.
Results:  The mean age of the patients was 48.21 ± 7.7 years. The mean systolic blood pressure was 132.37 ± 18.7, diastolic blood pressure was 84.24 ± 11.7, the mean duration of surgery was 138.16 ± 0.38 minutes, and the mean duration of recovery was 36.45 ± 11.3 minutes. In the group receiving dexamethasone plus ondansetron, the frequency of nausea and vomiting and need to analgesics were lower than other groups In the regression analysis, older age and higher blood pressure were associated with an increase in the frequency of nausea, and higher blood pressure and longer duration of surgery were associated with an increase in the frequency of vomiting and the need for analgesics.
Conclusion:  The combined administration of dexamethasone and ondansetron has a better effect in reducing the frequency of postoperative nausea and vomiting than their administration alone and reduces the need to prescribe analgesics. Our recommendation is combination of dexamethasone and ondansetron in prophylaxy of postoperative nausea and vomiting and reducing of need to analgesics in postoperative period at patients who undegoing of hysterectomy, especially at younger ages and in long-lasting operations.