Abstract
Introduction. The effectiven ess of ii-pattern primed-burst (PBs) for the indu ction of long-term potentiat ion (LTP) of populati on excita tory postsynaptic potenti al (pEPSP) a n d popul a ti o n spi kes (PS ) were inv es tigat e d in hipp o campa l CA l of pentylenetetrazol-kindled rats. Materials and Methods. Ex pe riments we re ca rried out in the co nt rol an d kindle d a nima ls. Fie ld po te nt ia ls (pEPS P a nd PS ) were re corded a t stratum radia tum and stra tum pyramidale fo llowing st imula t io n of th e strat um fibers, res pe ct ivel y. PBs was delivered to stratum fibers and PB potentiation was assessed. Results. Th e results showed th at 48-144 h after kindling PB potentiation in stra tum rad ia tum of kindled a nima ls was not significantly cha nged co mpa re d to co ntro ls. In stratum pyramida le PBs induced LTP in control animals but not in kindled ones. Conclusion . The e ffect is co mpatib le with the hypot hes is that postula te kin dling associated functional de ficit in hippocampus, especially CAl, as an expla na tion for the behavioral deficits seen with the kindling model of epilepsy
Keywords
Pe n tyl e ne t e tr azo l, Field potentials , Long- term potentia ti on , Hippocampus, Rat پنتیلن تترازول، پتانسیل های میدانی، تقویت طولانی مدت، هیپوکمپ، موش صحرایی
Copyright
© 2000, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.