Endothelium-dependent and –independent vascular effect of the flavonoid quercetin in thoracic aorta of diabetic rats

How to Cite:Mehrdad RoghaniTorandokht BalochMojaradEndothelium-dependent and –independent vascular effect of the flavonoid quercetin in thoracic aorta of diabetic rats.koomesh.6(3):e152058.

Abstract

Introduction: Quercetin is one of the most common forms of flavonoids in foodstuffs, which could have multiple beneficial effects on the cardiovascular system including an induction of vasorelaxation in conductance and resistive vessels. Due to changes in endothelial functionality in diabetes mellitus, there is an enhanced vascular responsiveness to contractile agonists. Therefore, the role of endothelium was evaluated in vasorelaxant effect of quercetin in diabetic rats. Materials and Methods: For this purpose, male Wistar rats were divided into control and diabetic groups. For induction of diabetes, streptozotocin (60 mg/Kg, i.p.) was used. The body weight and serum glucose parameters were determined before and at 2nd and 4th after the experiment. Contractile responsiveness to KCl and noreadrenalin (NA) and quercetin-induced vasorelaxation were measured at the end of study. Results: After 4 weeks, quercetin (1 mM-10 mM) induced a dose-dependent vasorelaxation in aortic rings precontracted with KCl andor NA from both control and diabetic groups (p

Keywords

Quercetin, Thoracic aorta, Endothelium, Diabetes mellitus, Rat

کوئرستین، آئورت سینه‌ای، اندوتلیوم، دیابت قندی، موش صحرایی

comments