Prospective evaluation of a new “ultra rapid paper urease test” for detecting the Helicobacter pylori in gastric mucosa

Shahrokh Mosavi; Fatemeh Moghadas; Vahid Semnani; raheb Ghorbani; Mehdi Babaie; Mojtaba Malek; Jafar Tosi

Koomesh

Journal of Semnan University of Medical Sciences

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Prospective evaluation of a new “ultra rapid paper urease test” for detecting the Helicobacter pylori in gastric mucosa

Author(s):

Shahrokh Mosavi^,*,

Fatemeh Moghadas,

Vahid Semnani,

raheb Ghorbani,

Mehdi Babaie,

Mojtaba Malek,

Jafar Tosi

Koomesh:Vol. 6, issue 4; 265-270

Published online:Aug 15, 2005

Article type:Research Article

Received:Sep 01, 2008

How to Cite:Shahrokh MosaviFatemeh MoghadasVahid Semnaniraheb GhorbaniMehdi BabaieMojtaba MalekJafar Tosiet al.Prospective evaluation of a new “ultra rapid paper urease test” for detecting the Helicobacter pylori in gastric mucosa.koomesh.6(4):e152065.

Abstract

Introduction: In order to determine a cheap, easy, simple and fast method with high accuracy to diagnose the Helicobacter pylori (HP) in patients with gastroendoscopy, this research has been performed. Thus, sensitivity, specificity, positive and negative predictive values of the utra rapid Paper uease test (URPUT) for the detection of the HP in gastric tissue has been studied. Materials and Methods: 100 Patients presenting for upper endoscopy with no recent exposure to HP-altering drugs were enrolled. Antral biopsy specimens were tested by the URPUT method and submitted for histology. Patients underwent [13C] urea breath tests (UBT) too. HP was considered as positive if either UBT or histology demonstrated HP, and negative if HP was not detected in both UBT and histology. The URPUT was reported at 15 minutes. Results: Sensitivity, specificity, positive and negative predictive values of URPUT were 87%, 100%, %100 and 53.5%, respectively. There wasn’t observed any significant relationship between speed of color change of paper in this method and the amount of UBT and also severity rate of bacteria in histology. Conclusions: In endoscopic candidate patients, URPUT can be used as a cheap, easy and fast method to diagnose HP.

Keywords

Helicobacter Pylori, URPUT, Rapid Urease test, Endoscopy

هلیکوباکتر پیلوری، تست اوره‌آز کاغذی،URPUT ، آندوسکوپی

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