Abstract
Introduction: We investigated the role of sex hormones on changes in brain edema intracranial pressure (ICP), cerebral perfusion pressure (CCP) after trauma brain injury (TBI) in ovarectomized female (OVX) rats.
Material and Methods: In this study female rats are divided into five groups. Control group (Intact) sham group and other groups include: vehicle, estrogen group (1mg/kg) and progesterone group (8 mg/kg) which on all groups TBI was induced by Marmarou method. 30 minutes after TBI, drugs were injected i.p. ICP was measured in spinal cord using a standard procedure. CPP was calculated by the mean arterial pressure (MAP) - ICP. Neurologic scores were measured by motor, eye and respiratory reflex
Results: The results showed after TBI, water content was significantly lower in estrogen and progesterone groups (P
Keywords
Estrogen, Progesterone, Neuroprotective, ICP, CPP, Brain edema, Neurologic outcome استروژن، پروژسترون، نوروپروتکتیو، فشار داخل جمجمهای، فشار پرفیوزن مغز، خیز مغزی، پیامدهای نورولوژیک
Copyright
© 2024, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.