Abstract
Introduction: Diabetes mellitus is accompanied with higher incidence of cardiovascular disorders. There is some evidence on antidiabetic potential of Allium ascalonicum L. (AA). Therefore, this study was conducted to evaluate the beneficial effect of oral two-month administration of AA on contractile reactivity of isolated thoracic aorta from diabetic rats. Materials and Methods: Male Wistar rats were divided into control, AA-treated control, diabetic, and AA-treated diabetic groups. For induction of diabetes, streptozotcin (STZ) was intraperitoneally administered (60 mg/Kg). Meanwhile, treated groups received AA mixed with standard pelleted food at a weight ratio of 6.25% for 2 months. Serum glucose level was measured in weeks 4 and 8. Also after 2 months contractile reactivity of thoracic aortic rings to KCl and noradrenaline was determined using isolated tissue setup. Results: Serum glucose level showed a significant increase in diabetic animals (p
Keywords
Allium ascalonicum L., Aorta, Diabetes Mellitus, Contractile Response موسیر، آئورت، دیابت قندی، پاسخ انقباضی
Copyright
© 2009, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.