Correlation of thrombotic factor with bleeding severity in patient’s with factor XI deficiency

Mohammad Faranosh; Ali JafarPor; Mahbobeh Rahmani; Mohammad Jazebi; Tahereh Shasani; Navid Danaie; GholamReza Mohammadi; Raheb Ghorbani

Koomesh

Journal of Semnan University of Medical Sciences

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Correlation of thrombotic factor with bleeding severity in patient’s with factor XI deficiency

Author(s):

Mohammad Faranosh,

Ali JafarPor,

Mahbobeh Rahmani,

Mohammad Jazebi,

Tahereh Shasani,

Navid Danaie,

GholamReza Mohammadi,

Raheb Ghorbani

^,*

Koomesh:Vol. 11, issue 1; 55-60

Published online:Mar 24, 2009

Article type:Research Article

How to Cite:Mohammad FaranoshAli JafarPorMahbobeh RahmaniMohammad JazebiTahereh ShasaniNavid DanaieGholamReza MohammadiRaheb Ghorbaniet al.Correlation of thrombotic factor with bleeding severity in patient’s with factor XI deficiency.koomesh.11(1):e152264.

Abstract

Introduction: Factor XI is a glycoprotein that important role in blood coagulation. The aim of this study is determine correlation of thrombotic factor and bleeding severity with factor XI deficiency. Materials and Methods: 24 patients with factor XI deficiency were included in this study. Following physical examination and interview, a questionnaire was filled for all the patients. A blood sample was collected for measurement of coagulation factors (II, V, VII, and VIII, IX, X, XI, XII, and XIII), fibrinogen, protein C, protein S, antithrombin III, PG20210A, factor V Leiden, MTHFR gene and Homocystein. Results: 54.2% and 45.8% of patients were male and female, respectively. Mean (±SD) age of patients was 27.2±13.6 (3-49) years. 45.8%, 29.2%, 25% of the patients showed mild, moderate and severe bleeding, respectively. Although, a significant positive correlation was observed between factor V and bleeding severity (P=0.033, r =0.491), there was no correlation between bleeding severity and other thrombotic factors. Conclusion: The findings showed that a positive correlation between factor XI deficiency and factor V. We need more studies as multicenter studies to detecting the relation of other thrombotic factors with bleeding severity in patients with factor XI deficiency

Keywords

Factor XI, Thrombotic factor, Coagulation factor, Bleeding severity

فاکتور ١١، عوامل ترومبوتیک، عوامل انعقادی، شدت خون‌ریزی

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