Abstract
Introduction: Considering the high incidence of patients with coronary artery disease (CAD) in the Iranian population and a preventive role of serum paraoxonase (PON1) in development of CAD, the present study was designed to determine the distribution of PON1 phenotypes in patients with CAD. Materials and Methods: A total of 61 patients with coronary stenosis of 70% were included in this study. Paraoxonase and arylesterase activities were measured using paraoxon and phenylacetate as substrate, respectively. Phenotyping of the PON1 Q192R polymorphism was determined by calculating the ratio of salt-stimulated paraoxonase activity to arylesterase activity (double-substrate method). Results: Patients with stenosis of 70% at ratios of 2.42 and 5.91. In patients with stenosis of 70% were 48%, 41% and 11%, respectively. Conclusions: Based on his study and other studies conducted in Iran, it can be concluded that in the Iranian population there is no statistically difference in phenotype distribution of PON1 between patients with CAD (with severe stenosis or mild stenosis) and healthy individuals.
Keywords
Phenotype distribution, Serum paraoxonase, Arylesterase, Coronary stenosis توزیع فنوتیپ، پاراکسوناز سرم، آریل استراز، گرفتگی عروق کرونر
Copyright
© 2011, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.