Association of the insulin gene polymorphism and colorectal cancer

Maral Arkani; Akram Safaei; Khatoon Karimi; Elham Arbabi; Fatemeh Rostami; Mitra Iman; Parvane Mohammadi; Elham Hamzeie; Mohsen Vahedi; Reza Mohebi; Mohamad Vafaei; Reza Fatemi

Koomesh

Journal of Semnan University of Medical Sciences

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Association of the insulin gene polymorphism and colorectal cancer

Author(s):

Maral Arkani,

Akram Safaei^,*,

Khatoon Karimi,

Elham Arbabi,

Fatemeh Rostami,

Mitra Iman,

Parvane Mohammadi,

Elham Hamzeie,

Mohsen Vahedi,

Reza Mohebi,

Mohamad Vafaei,

Reza Fatemi

Koomesh:Vol. 13, issue 2; 172-176

Published online:May 25, 2012

Article type:Research Article

Received:Jan 09, 2011

Accepted:Aug 27, 2011

How to Cite:Maral ArkaniAkram SafaeiKhatoon KarimiElham ArbabiFatemeh RostamiMitra ImanParvane MohammadiElham HamzeieMohsen VahediReza MohebiMohamad VafaeiReza Fatemiet al.Association of the insulin gene polymorphism and colorectal cancer.koomesh.13(2):e152505.

Abstract

Introduction: Some studies have determined that polymorphism in insulin gene are associated with increased insulin level and resistant to insulin and also cause to increase risk of colorectal cancer (CRC). The goal of this study was to evaluate incidence of the insulin gene polymorphism (rs689) in an Iranian population and to investigate the role of this polymorphism in increased risk of CRC. Materials and Methods: Genotyping of the insulin gene were determined in a series of 110 colorectal cancer patients and 110 controls by using polymerase chain reaction and restriction fragment length polymorphism genotyping assays (PCR-RFLP). Results: P value for genotype AT compared with AA, was 0.052 (OR=1.88, CI=0.99-3.5) and TT versus AA was 0.57 (OR=1.33 CI=0.48- 3.6). The results showed that the insulin gene polymorphism (rs689) is not a predisposing factor to increased risk to CRC (P=0.14). Incidence of mutant allele between patients and controls had no significant differences (OR=1.53 95% CI=0.98- 2.39, Pe=0.057). Conclusion: These findings suggest that the insulin gene polymorphism (rs689) is not associated with increased risk of CRC.

Keywords

Polymorphism, Colorectal neoplasms, Insulin resistance, rs 689

چند شکلی در ژنتیک، نورویش‌های کولون و راست روده، مقاومت به انسولین، 689 rs

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