Similar efficacy of vancomycin and teicoplanin in treatment of catheter related infection in hemodialysis patients

Mohamad Reza Tamadon; Alireza Soliemani; Malihe Yarmohamadi; Vahid Semnani; Farhad Malek; Mojtaba Malek; Raheb Ghorbani

Koomesh

Journal of Semnan University of Medical Sciences

Current Issue Archive In Press Accepted Manuscripts Search

Journal Information Editors & Boards Indexing and Listing Sources Journal Metrics Open Peer Review (OPR)Publication Ethics and Publication Malpractice Statement Support Contact Us Reviewer and AE Registration Form

APC

Authors Guide Submit Manuscript

Similar efficacy of vancomycin and teicoplanin in treatment of catheter related infection in hemodialysis patients

Authors:

Mohamad Reza Tamadon,

Alireza Soliemani,

Malihe Yarmohamadi,

Vahid Semnani,

Farhad Malek,

Mojtaba Malek^,*,

Raheb Ghorbani

Koomesh:Vol. 14, issue 1; 33-38

Published online:Mar 25, 2012

Article type:Research Article

Received:Jan 09, 2012

How to Cite:Mohamad Reza TamadonAlireza SoliemaniMalihe YarmohamadiVahid SemnaniFarhad MalekMojtaba MalekRaheb Ghorbaniet al.Similar efficacy of vancomycin and teicoplanin in treatment of catheter related infection in hemodialysis patients.14(1):e152546.

Abstract

Introduction: Catheter related infection is one of the most important complications of vascular access devices. Treatment of these complications is important and life saving. The most common causative organisms are gram-positive bacteria especially staphylococcus. Vancomycin and teicoplanin are two antibiotics which widely used for invasive beta-lactam-resistant Gram-positive infections. In this study, we aimed to compare efficacy of vancomycin and teicoplanin in treatment of catheter related infection. Material and Methods: In this clinical trial, 43 patients with catheter infection were enrolled. Diagnosis was based on clinical criteria. 22 patients were received teicoplanin 800mg intra-venous loading dose and 400mg at days 2th, 3th,5th,12th,19th and 21 patients received vancomycin 1gr intra venous loading dose and 500mg every 5 days and for 3 weeks. A criterion for treatment response was absence of fever after 72 hours. Results: %57.1 patients who received vancomycin and %68.2 patients who received teicoplanin had clinical response (p=0.454). In patients who received vancomycin, one case developed red man syndrome and one case developed diarrhea (9.5%) and in tiecoplanin group one patient developed rash (9.1%). Conclusion: Our findings show that there is no significant difference between two groups in treatment of catheter related infection in hemodialysis patients

Keywords

Teicoplanin, Vancomycin, Catheter-related infections, Renal dialysis

تیکوپلانین، ونکومایسین، عفونت های ناشی از سوند گذاری، دیالیز کلیوی

comments