Similar efficacy of vancomycin and teicoplanin in treatment of catheter related infection in hemodialysis patients

authors:

avatar Mohamad Reza Tamadon , avatar Alireza Soliemani , avatar Malihe Yarmohamadi , avatar Vahid Semnani , avatar Farhad Malek , avatar Mojtaba Malek , * , avatar Raheb Ghorbani ORCID


how to cite: Tamadon M R, Soliemani A, Yarmohamadi M, Semnani V, Malek F, et al. Similar efficacy of vancomycin and teicoplanin in treatment of catheter related infection in hemodialysis patients. koomesh. 2012;14(1):e152546. 

Abstract

  Introduction: Catheter related infection is one of the most important complications of vascular access devices. Treatment of these complications is important and life saving. The most common causative organisms are gram-positive bacteria especially staphylococcus. Vancomycin and teicoplanin are two antibiotics which widely used for invasive beta-lactam-resistant Gram-positive infections. In this study, we aimed to compare efficacy of vancomycin and teicoplanin in treatment of catheter related infection.   Material and Methods: In this clinical trial, 43 patients with catheter infection were enrolled. Diagnosis was based on clinical criteria. 22 patients were received teicoplanin 800mg intra-venous loading dose and 400mg at days 2th, 3th,5th,12th,19th and 21 patients received vancomycin 1gr intra venous loading dose and 500mg every 5 days and for 3 weeks. A criterion for treatment response was absence of fever after 72 hours.   Results: %57.1 patients who received vancomycin and %68.2 patients who received teicoplanin had clinical response (p=0.454). In patients who received vancomycin, one case developed red man syndrome and one case developed diarrhea (9.5%) and in tiecoplanin group one patient developed rash (9.1%). Conclusion: Our findings show that there is no significant difference between two groups in treatment of catheter related infection in hemodialysis patients