Unstable social situation and food inequality can promote accumulation of lipofuscin and induced apoptosis in hepatocytes

Fatemeh Moradi; Mohammad reza Vaez Mahdavi; Abolhassan Ahmadiani; Mehrdad Roghani; Taghi Altarihi; AliReza Selshad; Shahnaz Mojarab

Koomesh

Journal of Semnan University of Medical Sciences

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Unstable social situation and food inequality can promote accumulation of lipofuscin and induced apoptosis in hepatocytes

Authors:

Fatemeh Moradi,

Mohammad reza Vaez Mahdavi^,*,

Abolhassan Ahmadiani,

Mehrdad Roghani,

Taghi Altarihi,

AliReza Selshad,

Shahnaz Mojarab

Koomesh:Vol. 14, issue 1; 55-64

Published online:Feb 25, 2012

Article type:Research Article

Received:Dec 02, 2011

Accepted:May 02, 2012

How to Cite:Fatemeh MoradiMohammad reza Vaez MahdaviAbolhassan AhmadianiMehrdad RoghaniTaghi AltarihiAliReza SelshadShahnaz Mojarabet al.Unstable social situation and food inequality can promote accumulation of lipofuscin and induced apoptosis in hepatocytes.14(1):e152549.

Abstract

Introduction: Based on both animal and human studies, inequality and social injustice have adverse effects on individual and community health. However, it is not yet known whether social instability and food inequality can cause the premature aging hepatocytes death in young people. To address this question, the effects of food intake inequality with or without unstable social status were evaluated and histopathological changes in hepatocytes and aging process investigated as well. Material and Methods: Forty eight Newzeland white male rabbits were divided into six groups and different social situations were applied to some groups during eight weeks. After the end of the period of the experiment, lipofuscin accumulation and apoptosis as two main markers of aging were studied by long Zeihl Nelseen staining and the terminal deoxynucleotidyl transferase dUTP nike end labeling (TUNEL reaction) of the hepatocytes respectively. Serum cortisol level was also measured. Results: The simultaneous application of the mentioned situations (i.e. food restriction, social inequality and changed cage-mate), caused significant change in lipofuscin accumulation in the hepatocytes in comparison with the control group (p

Keywords

Social justice, Food deprivation, Socioeconomic factors, Lipofuscin, Aging , Rabbits

عدالت اجتماعی، محرومیت غذایی، عوامل اجتماعی اقتصادی، لیپوفوشین، پیری، خرگوش ها

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