Comparison the effects of fentanyl, sufentanil and alfentanil as premedication on post-operative nausea and vomiting in diagnostic gynecologic laparascopy

authors:

avatar Seyed Hossein Taravati , avatar Mohammad Reza Dorodian , avatar Sepideh BeygZadeh , avatar Mohammad shabani , *

Koomesh: Vol.14, issue 3; 285-291
published online: May 25, 2013
article type: Research Article
received: December 02, 2011
accepted: April 08, 2013

how to cite: Taravati S H, Dorodian M R, BeygZadeh S, shabani M. Comparison the effects of fentanyl, sufentanil and alfentanil as premedication on post-operative nausea and vomiting in diagnostic gynecologic laparascopy. koomesh. 2013;14(3):e152578. 

Abstract

 Introduction: Reduction of post-operative nausea and vomiting (PONV)) promotes discharge of patients and reduces healthcare costs, hospital re–admission and duration of stay of patients in hospital, and finally satisfies patients. In this study, the effects of three opioids that are used routinely in general anesthesia (alfentanil, sufentanil and fentanyl) were assessed on the incidence of PONV. Materials and Methods: In this double-blind clinical trial, one hundred eighty patients (ASA I and II), aged 18-35 year, were randomly allocated into three groups. All three groups were firstly received 1mg midazolam 2minutes before anesthesia and then each group received 2cc of one of following opioid drugs: Alfentanil, fentanyl and sufentail (the general anesthesia method was similar in three groups). PONV was assessed 2hrs and 2-24hrs in post-operative period in these three groups.  Results: Incidence of postoperative nausea was respectively 13.33 %, 35% and 41.6% in alfentanil, fentanyl and sufentailgroup in the first 24hrs of post-operative period. Incidence of nausea was significantly lower in alfentanil group in the first 2hrs (p