Incidence of post operative nausea and vomiting following induction and maintance of general anesthesia with propofol or induction by propofol and maintenance with isoflurane: A randomized clinical trial

 Introduction: Post operative nausea and vomiting (PONV) are one of the most common complications after surgery. One possible way for the solution of this problem is using a suitable drug for anesthesia. Propofol decreases the rate of PONV. As we know, no study used propofol as a single drug for general anesthesia. Thus, the aim of this study was to compare the incidence of PONV following anesthesia induction and maintenance by propofol with anesthesia induction by propofol and maintenance by isoflurane. Materials and Methods: In this clinical trial, 196 patients with ASA (American Society of Anesthesiologists) class I and II aged from 16 to 65 years old who were candidates for general, orthopedic and urology surgeries were chosen. The patients were randomly divided into two 98 person groups. In group A, propofol was used for induction and maintenance of anesthesia and in group B propofol and isoflurane were used for induction and maintenance of anesthesia, respectively. The incidence of PONV was recorded at 1 and 6 hours after the surgery. Results: The incidence of PONV in group A (propofol) was significantly lower than group B (propofol + isoflurane) in the first six hours after surgery. Conclusion: Our findings show that in comparison with propofol + isoflurane, using propofol for both induction and maintenance of anesthesia significantly decrease the incidence of PONV after general, orthopedic and urology surgeries.