Effect of prophylactic gabapentin on post-dural puncture headache in patients after cesarean section surgery

authors:

avatar Mahshid Nikooseresht ORCID , avatar Pouran Hajian ORCID , * , avatar Tahereh Afiati-vesal , avatar Abbas Moradi

Koomesh: Vol.24, issue 3; 320-326
published online: August 01, 2022
article type: Research Article
received: January 02, 2021
accepted: September 01, 2021

how to cite: Nikooseresht M , Hajian P, Afiati-vesal T, Moradi A. Effect of prophylactic gabapentin on post-dural puncture headache in patients after cesarean section surgery. koomesh. 2022;24(3):e152741. 

Abstract

Introduction: Post-dural puncture headache (PDPH) is the most common complication of spinal anesthesia. Numerous drugs have been proposed to prevent or treat post spinal headache, but no definitive treatment is still available. Gabapentin has widely been used for prophylaxis or treatment of different types of headache, so in this study, the preventive effect of gabapentin on PDPH after cesarean section surgery was evaluated. Materials and Methods: 100 eligible pregnant women candidate for elective cesarean section were evaluated in this prospective double blind randomized study in two groups: intervention (gabapentin 600 milligram, n=50) and control (placebo, n=50). Patients received oral medications two hours before performing the spinal anesthesia and were followed up for three days after surgery, asked about the occurrence and severity of headache, analgesic consumption and any complications like drowsiness or vertigo.. Results: Two study groups were similar in terms of age, gestational age, height and weight (P>0.05). The overall incidence of headache in the intervention group (6%, N=3) was significantly lower than the control group (20%, n=10) (P

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