Comparison of the effect of ginger by skin patch and oral capsule on pain intensity, joint dryness, and daily functioning of patients with knee osteoarthritis

authors:

avatar Zeinab Alipour , avatar Mehran Naghibeiranvand ORCID , avatar Marzieh Asadizaker ORCID , * , avatar Sedigheh Fayazi , avatar Nima Yeganeh , avatar Maryam Kouchak , avatar Mohammah-Hossein Haghighizadeh

Koomesh: Vol.24, issue 6; 818-825
published online: December 02, 2022
article type: Research Article
received: November 02, 2021
accepted: June 02, 2022

how to cite: Alipour Z, Naghibeiranvand M, Asadizaker M, Fayazi S, Yeganeh N, et al. Comparison of the effect of ginger by skin patch and oral capsule on pain intensity, joint dryness, and daily functioning of patients with knee osteoarthritis. koomesh. 2022;24(6):e152794. 

Abstract

Introduction: Knee osteoarthritis is the most common arthritis and musculoskeletal disease. The low efficacy and significant side effects of synthetic drugs in the treatment of this disease have led many researchers to look for a drug that is effective but has fewer side effects. Recently, ginger is one of the most popular herbal remedies in the treatment of this disease. This study aimed to compare the effect of ginger by skin patch and oral capsule on pain intensity, joint dryness, and daily performance of patients with osteoarthritis of the knee. Materials and Methods: This was a three-group clinical trial study that was performed on patients referred to Afshar orthopedic clinic in Dezful in 2015. Sampling was available. Subjects were randomly divided into three groups according to the table of random numbers: skin patch, ginger capsule, and control. All three groups received treatment prescribed by an orthopedic specialist. In addition, the ginger capsule group used 2 500 mg ginger capsules daily and the ginger skin patch group used one ginger skin patch daily in the middle of the waist for 9 weeks. The data collection tool was a demographic questionnaire and a translated version of the Arthritis Index of Western Ontario and McMaster Universities (WOMAC). One-way analysis of variance, paired t-test, and Tukey post hoc test aswas used to analyze the data. A significant level were considered 0.05. Results: The total number of participants in the study was 135.In the groups of ginger capsules, ginger skin patch, and control. the mean pain intensity before the intervention was 13.08, 14.52, and 13.55, respectively, and after the intervention, it decreased to 7.05, 8.62, and 11.37(P<0.00). Conclusion: Ginger in both oral capsules and skin patches is effective in reducing the severity of pain and dysfunction in patients with osteoarthritis of the knee. It seems that only oral capsules reduce joint dryness and the ginger skin patch is ineffective.

References

  • 1.

    V.C. Mow, RH Uiskes. Basic Orthopaedic biome chanics and mechanobiology.4.234.25, Philadelphia: Lippincott Williams and Wilkins, 3th edition, 2005.

  • 2.

    Feslsone DT. Osteoarthritis. In: Lango DL, Hauser SL, Jameson JL, Loscalzo J, editors. Harisons principals of Internal Medicine. 18thed NeuYork: Mc Graw-Hill; 2012.

  • 3.

    Davatchi F, Jamshidi AR, Banihashemi AT, Gholami J, Forouzanfar MH, Akhlaghi M, et al. WHO-ILAR COPCORD study in Iran. J Rheumatol 2008; 35: 1384.

  • 4.

    Williamson L, Wyatt MR, Yein K, Melton JT. Sever knee osteoarthritis: a randomized controlled trial of acupuncture, physiotherapy (supervised exercised) and standard management for patients awaiting knee replacement. Rheumatology (Oxford) 2007; 46: 1445-1449.

  • 5.

    Vincen KR, Vasilopouls T, Montero C, Vincent HK. Eccentric and concentric resistance exercise comparison for knee Osteoarthritis. Med Sci Sport Exerc 2019; 51: 1977-1986.

  • 6.

    Coleman S, McQuade J, Rose J, Inderjeeth C, Carroll G, Briffa NK. Self- management for osteoarthritis of the knee: does mode of delivery influence outcome? BMC Musculoskeletal Disord 2010; 11: 56.

  • 7.

    Shamsipour dehkordi P, Abdoli B, Modaberi S. Effectiveness of physical activity on qualify of life elderiy patients with osreoarthritis. J Shahrekord Univ Med Sci 2012; 14: 92-101. (Persian).

  • 8.

    Simms RW. Osteoarthritis. In: Andreli TE, Carpenter CJ, Cecil RF. Andreoli and Carpenters Cecil essential of medicine.7th.philadelphia: Saunders Company 2007; 845-847.

  • 9.

    Stannus O, Jones G, Cicuttini F, Parameswarn V, Quinn S, Burgess J, et al. Circulating levels of TNF-alpha are associated with Knee radiographic osteoarthritis and Knee cartilage loss in older adults. Osteoarthritis Cartilage 2010; 18: 1441-1447.

  • 10.

    Hadler NM. Knee pain is the malady-not osteoarthritis. Ann Intern Med 1992; 116: 598-599.

  • 11.

    Harrison. Harrison Principles of Internal Medicine, Rheumatology and immune system diseases, translated by Seyyed Mahdi. Tehran: Tehran book publishing venerable 2012; 313-296.

  • 12.

    Chopra A, Patil J, Bilampelly V, Relwane J, Tandle HS. Prevalence of rheumatic disease in rural population in western India. a WHO-ILAR COPCORD study. J Assoc Physicians India 2001; 49: 240-246.

  • 13.

    Jamtvedt G, Dahm KT, Christie A, Moe RH, Haavardsholm E, Holm I, et al. Physical therapy interventions for patients with osteoarthritis of the knee: an overview of systematic reviews. Phys Ther 2008; 88: 123-136.

  • 14.

    Hunt R, Lanas A, Stichtenoth D. Myths and facts in the use of antiinflammatory drugs. Ann Med 2009; 8: 1-16.

  • 15.

    Silverstein FE, Fach G, Goldstein JL, Simon LS, Pincus T, Whelton A, et al. Gastrointestinal toxicity with celecoxib vs nonsteroidal anti-inflammatory drugs for osteoarthritis and rheumatoid arthritis: the class study: a randomized controlled trial. JAMA 2000; 284: 1247-1255.

  • 16.

    Hadadian F. The effect electrical simulation of acupuncture points Pierre skin fatigue hemodialysis patients Maintenance. Ahvaz Univ Med Sci 2009. (Persian).

  • 17.

    Lapane K, Sands M, Yang S, Mc Alindon T, Eaton C. Use of complementary and alternative medicine among patients with radiographic-confirmed Knee Osteoarthritis. Osteoarthritis Cartilage 2012; 20: 22-28.

  • 18.

    Argoff CE. Recent developmentsin the treatment of osteoarthritis with NSAIDs. Curr Med Res Opin 2011; 27: 1315-1327.

  • 19.

    Li H, Liu Y, Luo D, Ma Y, Zhang J, Li M, et al. Ginger for heaith care: An overview of systematic reviews. Complement Ther Med 2019; 45: 114-123.

  • 20.

    Ali BH, Blunden G, Tanira MO, Nemmar A. Some phytochemical, pharmacological and toxical properties of ginger (Zingiber officinale Roscore): A review of recent research. Food Chem Toxiocol 2008; 46: 409-420.

  • 21.

    Mahomoodally MF, Aumeeruddy MZ, Rengasamy KR, Roshan S, Hammad S, Pandohee J, et al. Ginger and its active compounds in cancer therapy: From folk uses to nano- therapeutic applications. Semin Cancer Bio 2021; 69: 140-149.

  • 22.

    Nile SH, Park SW. Chromatographic analysis, antioxidant, anti- inflammatory, and xanthine oxidase inhibitory activities of ginger extracts and its reference compounds. Indust Crops Products 2015; 70: 238-244.##https://doi.org/10.1016/j.indcrop.2015.03.033.

  • 23.

    Grazanna R, Lindmark L, Frondoza CG. Ginger - an herbal medicinal product with broad anti - inflamatory actions. J Med Food 2005; 8: 125-132.

  • 24.

    Haghighi M, KHalvat A, Tolit T, Jallaei S. Comparing the effects of ginger (Zingiber Officinale) extract and ibuprofen on patients with osteoarthritis. Arch Iran Med 2005; 8: 267-271.

  • 25.

    Babashahi M. Comparison effect of massage aromathrapy and inhallation aromathrapy on level of anexiety in preoperative patients [master thesis]. Ahvaz. Ahvaz Jondishapour Univ Med Sci Fact Nurs Midwifery 2008. (Persian).

  • 26.

    Mao QQ, Xu XY, Cao SY, Gan RY, Croke H, Beta T, Li HB. Bioactive compounds and bioactivities of ginger (Zingiber officinale Roscoe). Foods 2019; 30: 8: 185.

  • 27.

    Crichton M, Marshall S, Marx W, McCarthy AL, Isenring E. Efficacy of ginger (Zingiber officinal) in ameliorating chemotherapy- include nausea and vomiting and chemotherapy-related outcomes: A systematic review update and meta-analys. J Acad Nutr Diet 2019; 119: 2055-2068.

  • 28.

    Higgins JP, Altman DG, Gtzsche PC, Jni P, Moher D, Oxman AD, et al. The Cochrane collaborations tool for risk of bias in randomized trials. BMJ 2011; 343: d5928.

  • 29.

    Chen CX, Barrett B, Kwekkeboom KL. Efficacy of oral ginger (Zingiber officinale) for dysmenorrhea: A systematic review and Meta - analysis. Evid Based Complement Altren Med 2016; 10.

  • 30.

    Naderi Z, Mozaffari-Khosravi H, Dehghan A, Fallah Hosseini H, Nadjarzadeh A. The effect of ginger (Zingiber Officinale) powder supplement on pain in patients with knee osteoarthritis: a Double-Blind randomized clinical trial. JSSU 2013; 20: 657-667. (Persian).

  • 31.

    Terkleson T. Topical ginger treatment with a compress or patch for osteoarthritis symptoms. J Holistic Nurs Am Holistic Nurs Assoc 2014; 32: 173-182.

  • 32.

    Salaffi F, Piva S, Barreca C, Cacace E, Ciancio G, Leardini G, et al. Validation of and Italian version of the arthritis impact measurement scale 2 (Italian-AIMS2) for patient with osteoarthritis of the knee. Rheum 2000; 39: 720-727.

  • 33.

    Ebrahimzadeh MH, Makhmalbaf H, Birjaninejad A, Golhasani Keshtan F, Hoseini HA, Mazloumi SM. The western ontario and mcmaster universiries osteoarthritis index (WOMAC (in Persian speaking patients with knee osteoarthritis. Arch Bone Jt Surg 2014; 2: 57-62.

  • 34.

    Bilbao A, Quintana JM, Escobar A, Las Hayas C, Orive M. Validation of a proposal WOMAC short form for patients with hip osteoarthritis. Health Qual Life Outcomes 2011; 9: 75.

  • 35.

    Xie F, Pullenayegum EM, Li SC, Hopkins R, Thumboo J, LoNN. Use of a disease specific instrument in economic evaluations: mapping WOMAC onto the EQ-5D utility index. Value Health 2010; 13: 873-878.

  • 36.

    Bartels EM, Folmer VN, Bliddal H, Altman RD, Juhl C, Tarp S, et al. Efficacy and safety of ginger in osteoarthritis patients: a Meta -analysis of randomized placebo- controlled trials. Osteoarthritis Cartilage 2015; 23: 13-21.

  • 37.

    Alipour Z, Asadizaker M, Fayazi S,Yegane N, Kochak M, et al. The effect of ginger on pain and satisfaction of patients with knee osteoarthritis. Jundishapur J Chronic Dis Care 2017; 6; e34798. (Persian).##https://doi.org/10.17795/jjcdc-34798.

  • 38.

    Anh NH, Kim SJ, Long NP, Min JE, Yoon YC, Lee EG, et al. Ginger on human health: a comprehensive systematic review of 109 randomized controlled trials. Nutrients 2020; 12: 157.

  • 39.

    Naderi Z, Mozaffari-Khosravi H, Dehghan A, Fallah Hosseini H, Nadjarzadeh A. The effect of ginger (zingiber officinale) powder supplement on pain in patients with knee osteoarthritis: a double-blind randomized clinical trial. J Shahid Sadoughi Univ Med Sci 2012; 20: 657-667. (Persian).

  • 40.

    Zakeri Z, Izadi S, Bari Z, Soltani F, Narouie B, Ghasemi-rad M. Evaluating the effects ginger extract on knee pain, stiffness and difficulty in patients with knee osteoarthritis. J Med Plants Res 2011; 5: 3375-3379. (Persian).

  • 41.

    Ramezani M, Nekozad N. Comparison between the effectiveness of glucosamine sulfate and zintoma on clinical improvement of knee osteoarthritis. Ebnesina J Med 2011; 14: 29-34. (Persian).