The effect of Nordic training on plasma levels of Peroxisome proliferator-activated receptor-γ coactivator 1-α and Sirtuin 6 in elderly women with diabetes

authors:

avatar Monireh Lalei , avatar Rouhollah Haghshenas , *

Koomesh: Vol.25, issue 1; 65-70
published online: March 06, 2023
article type: issue_documents_importer
received: April 02, 2022
accepted: November 06, 2022

how to cite: Lalei M, Haghshenas R. The effect of Nordic training on plasma levels of Peroxisome proliferator-activated receptor-γ coactivator 1-α and Sirtuin 6 in elderly women with diabetes. koomesh. 2023;25(1):e152803. 

Abstract

Introduction: Nordic walking training has many benefits in improving the condition of the disabled elderly. Then the aim of this study was to evaluate the effect of Nordic walking training on plasma levels of PGC1α and SIRT6 in elderly women with diabetes. Materials and Methods: In this quasi-experimental study, 27 elderly women (age: 65.45±2.70 years) with type 2 diabetes were selected and randomly divided into control groups (n=14) and experimental groups (n= 13). Then, the experimental group performed exercise protocol of Nordic walking training, three days per week for eight weeks. Blood samples were collected before and after the training protocol. ELISA kit was used to measure the biochemical variables of the research. Results: The analysis of data showed that the levels of PGC1α and SIRT6 in the exercise group compared to the control group increased significantly (P<0.001) and glucose, insulin and resistance of insulin decreased significantly (P<0.001). Conclusion: Nordic walking training, could reduce glucose, insulin and resistance insulin and increases PGC1α and SIRT6 in elderly women with diabetes, and help improve the metabolic system of the elderly.

References

  • 1.

    Li Y, Jin J, Wang Y. SIRT6 widely regulates aging, immunity, and cancer. Front Oncol 2022; 12: 861334.

  • 2.

    Kauppila TES, Kauppila JHK, Larsson NG. Mammalian mitochondria and aging: an update. Cell Metab 2017; 25: 57-71.

  • 3.

    Gilani N, Esmaeili A. Haghshenas R. The effect of eight weeks concurrent training and supplementation of L_Arginine on plasma level of 8-hydroxydeoxyguanosine (8-OHdG), malondialdehyde and total antioxidant capacity in elderly men (Multivariate Longitudinal Modeling). Iran J Endoc Metab 2018; 20: 195-202. (Persian).

  • 4.

    Guo Z, Li P, Ge J, Li H. SIRT6 in aging, metabolism, inflammation and cardiovascular diseases. Aging Dis 2022; 15.

  • 5.

    Gao S, Yang Q, Peng Y, Kong W, Liu Z, Li Z, et al. SIRT6 regulates obesity-induced oxidative stress via ENDOG/SOD2 signaling in the heart. Cell Biol Toxicol 2022; 1-19.##https://doi.org/10.1007/s10565-022-09735-z.

  • 6.

    Ji Z, Liu GH, Qu J. Mitochondrial sirtuins, metabolism, and aging. J Genet Genomics 2022; 49: 287-298.

  • 7.

    Khan RI, Nirzhor SSR, Akter R. A review of the recent advances made with SIRT6 and its implications on aging related processes, major human diseases, and possible therapeutic targets. Biomolecules 2018; 8: 44.

  • 8.

    alkan Z, Mutlu T, Gven M, Tundemir M, Niyaziolu M, Hacioglu Y, et al. SIRT6 expression and oxidative DNA damage in individuals with prediabetes and type 2 diabetes mellitus. Genet 2018; 642: 542-548.

  • 9.

    Vernier M, Gigure V. Aging, senescence and mitochondria: the PGC-1/ERR axis. J Mol Endoc 2021; 66: R1-R14.

  • 10.

    Puigserver P, Rhee J, Donovan J, Walkey CJ, Yoon JC, Oriente F, et al. Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1 interaction. Nature 2003; 423: 550-555.

  • 11.

    Gilani N, Haghshenas R, Esmaeili M. Application of multivariate longitudinal models in SIRT6, FBS, and BMI analysis of the elderly. Aging Male 2019; 22: 260-265.

  • 12.

    Vatankhah-khozani S, Haghshenas R, Faramarzi M. The effect of 8 weeks of elastic band resistance training on serum myostatin and body composition in elderly women. J Sport Biosciences 2018; 10: 347-358.

  • 13.

    Gilani N, Zamani Rad F, Ebrahimi M, Haghshenas R. Effect of eight weeks endurance training on ovarian androgens in women with polycystic ovary syndrome: application of multivariate longitudinal models. Int J Appl Exerc Physiol 2019; 8: 757-762.

  • 14.

    Nori P, Haghshenas R. Effects of eight weeks aerobic training on kynurenine and gene and protein expression of aryl hydrocarbon receptor in the heart of male rats. Koomesh 2022; 24: 162-167. (Persian).

  • 15.

    Soori R, Ravasi AA, Azarmohammad R, Ranjbar K, Pournemati P. Effects of 12 weeks concurrent aerobic and resistance training on serum vaspin and C-reactive protein levels in obese middle-aged men. Koomesh 2020; 22: 365-371. (Persian).##https://doi.org/10.29252/koomesh.22.2.365.

  • 16.

    Mohsenzadeh M, Aghaei F, Nameni F. The effect of high intensity interval training on SIRT1 and PGC1- gene expression in soleus muscle of type 2 diabetes in male rat. Med J Tabriz Univ Med Sci 2020; 42: 447-455. (Persian).##https://doi.org/10.34172/mj.2020.067.

  • 17.

    Witkowska A, Grabara M, Kope D, Nowak Z. The effects of nordic walking compared to conventional walking on aerobic capacity and lipid profile in women over 55 years of age. J Phys Act Health 2021; 18: 669-676.

  • 18.

    Podsiado S, Skiba A, Kaua A, Ptaszek B, Stoek J, Skiba A, et al. Influence of nordic walking training on Vitamin D level in the blood and quality of life among women Aged 65-74. Healthcare 2021; 9: 1146.

  • 19.

    Rodrigues IB, Ponzano M, Butt DA, Bartley J, Bardai Z, Ashe MC, et al. The effects of walking or nordic walking in adults 50 years and older at elevated risk of fractures: a systematic review and meta-analysis. J Aging Phys Act 2021; 29: 886-899.

  • 20.

    Sobhani F, Haghshenas R, Rahimi M. Effect of eight weeks aerobic training and supplementation of green tea on apelin plasma levels and insulin resistance in elderly women with type 2 diabetes. J Mazandaran Univ Med Sci 2019; 28: 84-93. (Persian).

  • 21.

    Kortas J, Kuchta A, Prusik K, Prusik K, Ziemann E, Labudda S, et al. Nordic walking training attenuation of oxidative stress in association with a drop in body iron stores in elderly women. Biogerontology 2017; 18: 517-524.

  • 22.

    Sugiyama K, Kawamura M, Tomita H, Katamoto S. Oxygen uptake, heart rate, perceived exertion, and integrated electromyogram of the lower and upper extremities during level and Nordic walking on a treadmill. J Physiol Anthropol 2013; 32: 1-9.

  • 23.

    Takeshima N, Islam MM, Rogers ME, Rogers NL, Sengoku N, Koizumi D, et al. Effects of nordic walking compared to conventional walking and band-based resistance exercise on fitness in older adults. J Sports Sci Med 2013; 12: 422.

  • 24.

    Sellami M, Gasmi M, Denham J, Hayes LD, Stratton D, Padulo J, et al. Effects of acute and chronic exercise on immunological parameters in the elderly aged: can physical activity counteract the effects of aging? Front Immunol 2018; 9: 2187.

  • 25.

    Shykholeslami Z, Abdi A, Barari A, Hosseini SA. The effect of aerobic training with Citrus aurantium L. on SIRT1 and PGC-1 gene expression levels in the liver tissue of elderly rats. Jorjani Biomed J 2019; 7: 57-65. (Persian).##https://doi.org/10.29252/jorjanibiomedj.7.4.57.

  • 26.

    Gram B, Christensen R, Christiansen C, Gram J. Effects of nordic walking and exercise in type 2 diabetes mellitus: a randomized controlled trial. Clin J Sport Med 2010; 20: 355-361.

  • 27.

    Gomeuka NA, Oliveira HB, da Silva ES, Passos-Monteiro E, da Rosa RG, Carvalho AR, et al. Nordic walking training in elderly, a randomized clinical trial. Part II: Biomechanical and metabolic adaptations. Sports Med Open 2020; 6: 1-19.

  • 28.

    Wasserfurth P, Nebl J, Rhling MR, Shammas H, Bednarczyk J, Koehler K, et al. Impact of dietary modifications on plasma sirtuins 1, 3 and 5 in older overweight individuals undergoing 12-Weeks of circuit training. Nutrients 2021; 13: 3824.

  • 29.

    Zhong L, D'Urso A, Toiber D, Sebastian C, Henry RE, Vadysirisack DD, et al. The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha. Cell 2010; 140: 280-293.

  • 30.

    Vargas-Ortiz K, Prez-Vzquez V, Macas-Cervantes MH. Macas-Cervantes, Exercise and sirtuins: a way to mitochondrial health in skeletal muscle. Int J Mol Sci 2019; 20: 2717.

  • 31.

    Kanfi Y, Peshti V, Gil R, Naiman S, Nahum L, Levin E, et al. SIRT6 protects against pathological damage caused by dietinduced obesity. Aging Cell 2010; 9: 162-173.

  • 32.

    Roichman A, Elhanati S, Aon MA, Abramovich I, Di Francesco A, Shahar Y, et al. Restoration of energy homeostasis by SIRT6 extends healthy lifespan. Nat Commun 2021; 12: 1-18.

  • 33.

    Asadi Samani Z, Rahnama N, Reisi J, Lenjan Nejadian S. Correlation between new activity-based balance index with accelerometer data and postural balance in elderly woman. Koomesh 2020; 22: 92-98. (Persian).##https://doi.org/10.29252/koomesh.22.1.92.

  • 34.

    Colman E, Katzel LI, Rogus E, Coon P, Muller D, Goldberg AP. Weight loss reduces abdominal fat and improves insulin action in middle-aged and older men with impaired glucose tolerance. Metabolism 1995; 44: 1502-1508.

  • 35.

    Mordarska K, Godziejewska-Zawada M. Diabetes in the elderly. Przeglad menopauzalny/Menopause review 2017; 16: 38.

  • 36.

    Madani P, Mohsen Avandi S, Haghshenas R, Pakdel A. Combined effect of eight weeks high intensity resistance training with ginger supplementation on waist to hip ratio, body composition and body mass in obese women. Koomesh 2017; 9: 286-293. (Persian).

  • 37.

    Chang AM, Halter JB. Aging and insulin secretion. Am J Physiol Endocrinol Metab 2003; 284: E7-E12.

  • 38.

    Osali A. Effect of six-week aerobic exercise and consumption of nanocurcumin on TNF- and memory in 60-65 years old women with metabolic syndrome. Koomesh 2018; 20: 503-509. (Persian).##https://doi.org/10.34172/mj.2019.002.

  • 39.

    Sentinelli F, La Cava V, Serpe RO, Boi A, Incani MI, Manconi ET, et al. Positive effects of Nordic Walking on anthropometric and metabolic variables in women with type 2 diabetes mellitus. Sci Sports 2015; 30: 25-32.##https://doi.org/10.1016/j.scispo.2014.10.005.