Logo

Anti-inflammatory and anti-oxidative effects of Ganoderma lucidum on liver injury induced by doxorubicin in rats

Author(s):
Reza Hemmatan AtarbashiReza Hemmatan Atarbashi, Amir RezaKaramibonariAmir RezaKaramibonari,*, Tarlan FarahvashTarlan Farahvash

Koomesh:Vol. 25, issue 3; 289-298
Published online:Jul 02, 2023
Article type:Research Article
Received:Jul 02, 2022
Accepted:Jul 02, 2023
How to Cite:Reza Hemmatan AtarbashiAmir RezaKaramibonariTarlan FarahvashAnti-inflammatory and anti-oxidative effects of Ganoderma lucidum on liver injury induced by doxorubicin in rats.koomesh.25(3):e152827.

Abstract

References

  • 1.
    Andrejc DC, Knez Z, Marevci MK. Antioxidant, antibacterial, antitumor, antifungal, antiviral, anti-inflammatory, and nevro-protective activity of Ganoderma lucidum: An overview. Front Pharmacol 2022; 2757.
  • 2.
    Gao JJ, Min BS, Ahn EM, Nakamura N, Lee HK, Hattori M. New triterpene aldehydes, lucialdehydes A-C, from Ganoderma lucidum and their cytotoxicity against murine and human tumor cells. Chemic Pharmac Bulletin 2002; 50: 837-840.
  • 3.
    Hu Z, Du R, Xiu L, Bian Z, Ma C, Sato N, et al. Protective effect of triterpenes of Ganoderma lucidum on lipopolysaccharide-induced inflammatory responses and acute liver injury. Cytokine 2020; 127: 154917.
  • 4.
    Liu GQ, Zhang KC. Mechanisms of the anticancer action of Ganoderma lucidum (Leyss. ex Fr.) Karst. a new understanding. Integrative Plant Bio 2005; 47: 129-135.##https://doi.org/10.1111/j.1744-7909.2005.00037.x.
  • 5.
    Wang YY, Khoo KH, Chen ST, Lin CC, Wong CH, Lin CH. Studies on the immuno-modulating and antitumor activities of Ganoderma lucidum (Reishi) polysaccharides: functional and proteomic analyses of a fucose-containing glycoprotein fraction responsible for the activities. Bioorganic Med Chem 2002; 10: 1057-1062.
  • 6.
    El-Mekkawy S, Meselhy MR, Nakamura N, Tezuka Y, Hattori M, Kakiuchi N, et al. Anti-HIV-1 and anti-HIV-1-protease substances from Ganoderma lucidum. Phytochem 1998; 49: 1651-1657.
  • 7.
    Fang QH, Tang YJ, Zhong JJ. Significance of inoculation density control in production of polysaccharide and ganoderic acid by submerged culture of Ganoderma lucidum. Process Biochem 2002; 37: 1375-1379.
  • 8.
    Su CY, Shiao MS, Wang CT. Potentiation of ganodermic acid S on prostaglandin E1-induced cyclic AMP elevation in human platelets. Thrombosis Res 2000; 99: 135-145.
  • 9.
    Saltarelli R, Ceccaroli P, Iotti M, Zambonelli A, Buffalini M, Casadei L, et al. Biochemical characterisation and antioxidant activity of mycelium of Ganoderma lucidum from Central Italy. Food Chem 2009; 116: 143-151.##https://doi.org/10.1016/j.foodchem.2009.02.023.
  • 10.
    Lin WC, Lin WL. Ameliorative effect of Ganoderma lucidum on carbon tetrachloride-induced liver fibrosis in rats. Gastroenterology 2006; 12: 265.
  • 11.
    Park EJ, Ko G, Kim J, Sohn DH. Antifibrotic effects of a polysaccharide extracted from Ganoderma lucidum, glycyrrhizin, and pentoxifylline in rats with cirrhosis induced by biliary obstruction. Biol Pharm Bull 1997; 20: 417-420.
  • 12.
    Ahmed OM, Galaly SR, Raslan M, Mostafa MA. Thyme oil and thymol abrogate doxorubicin-induced nephrotoxicity and cardiotoxicity in Wistar rats via repression of oxidative stress and enhancement of antioxidant defense mechanisms. Biocell 2020; 44: 41.##https://doi.org/10.32604/biocell.2020.08157.
  • 13.
    Shamsi F. Nanotechnology application in cancer treatment. Koomesh 2019; 21: 579-589. (Persian).
  • 14.
    Shahani S, Sahranavard M, Amiri F, Abedi M, Noaparast Z. Beneficial effects of Pimpinella anisum L. ethanol and aqueous extracts on L-asparaginase-associated hepatotoxicity using specific 99mTc-Phytate biodistribution studies in rats. Koomesh 2022; 24: 554-565. (Persian).
  • 15.
    El-Moselhy MA, El-Sheikh AA. Protective mechanisms of atorvastatin against doxorubicin-induced hepato-renal toxicity. Biomed Pharmacother 2014; 68: 101-110.
  • 16.
    Altnkaynak Y, Kural B, Akcan BA, Bodur A, zer S, Yulu E, et al. Protective effects of L-theanine against doxorubicin-induced nephrotoxicity in rats. Biomed Pharmacother 2018; 108: 1524-1534.
  • 17.
    Yagmurca M, Erdogan H, Iraz M, Songur A, Ucar M, Fadillioglu E. Caffeic acid phenethyl ester as a protective agent against doxorubicin nephrotoxicity in rats. Clin Chim Acta 2004; 348: 27-34.
  • 18.
    Kuzu M, Yldrm S, Kandemir FM, Kkler S, alayan C, Trk E, et al. Protective effect of morin on doxorubicin-induced hepatorenal toxicity in rats. Chem Biol Interact 2019; 308: 89-100.
  • 19.
    Hadi N, Yousif NG, Al-Amran FG, Huntei NK, Mohammad BI, Ali SJ. Vitamin E and telmisartan attenuates doxorubicin induced cardiac injury in rat through down regulation of inflammatory response. BMC Cardiovas Dis 2012; 12: 1-7.
  • 20.
    Fathima AT, Reenaa M. Anticancer and antibacterial activity of ganoderma lucidum. Int J Curr Microbiol App Sci 2016; 5: 891-909.##https://doi.org/10.20546/ijcmas.2016.510.097.
  • 21.
    Hassan HM, Al-Wahaibi LH, Elmorsy MA, Mahran YF. Suppression of cisplatin-induced hepatic injury in rats through alarmin high-mobility group box-1 pathway by Ganoderma lucidum: theoretical and experimental study. Drug Des Dev Ther 2020; 14: 2335.
  • 22.
    Uchiyama M, Mihara M. Determination of malonaldehyde precursor in tissues by thiobarbituric acid test. Anal Biochem 1978; 86: 271-278.
  • 23.
    Aebi H. Catalase in vitro. Methods Enzymol 1984; 105: 121-126.
  • 24.
    Peinnequin A, Mouret C, Birot O, Alonso A, Mathieu J, Clarenon D, et al. Rat pro-inflammatory cytokine and cytokine related mRNA quantification by real-time polymerase chain reaction using SYBR green. BMC Immunol 2004; 5: 1-0.
  • 25.
    Rolo AP, Teodoro JS, Palmeira CM. Role of oxidative stress in the pathogenesis of nonalcoholic steatohepatitis. Biol Med 2012; 52: 59-69.
  • 26.
    Al-Oanzi ZH, Elasbali AM, Alruwaili NK, Alotaibi NH, Alharbi KS, Alzarea AI, et al. Protective effect of baicalein alone and losartan-baicalein combination therapy on doxorubicin-induced hepatotoxicity in rats. Toxicol Environ Health Sci 2020; 12: 45-54.##https://doi.org/10.1007/s13530-020-00037-7.
  • 27.
    Shaker RA, Abboud SH, Assad HC, Hadi N. Enoxaparin attenuates doxorubicin induced cardiotoxicity in rats via interfering with oxidative stress, inflammation and apoptosis. BMC Pharmacother Toxicol 2018; 19: 3.
  • 28.
    Saltarelli R, Ceccaroli P, Iotti M, Zambonelli A, Buffalini M, Casadei L, et al. Biochemical characterisation and antioxidant activity of mycelium of Ganoderma lucidum from Central Italy. Food Chem 2009; 116: 143-151.##https://doi.org/10.1016/j.foodchem.2009.02.023.
  • 29.
    Fernandez ML, West KL. Mechanisms by which dietary fatty acids modulate plasma lipids. J Nutr 2005; 135: 2075-2078.
  • 30.
    Lin LJ, Shiao MS, Yeh SF. Seven new triterpenes from Ganoderma lucidum. J Nat Prod 1988; 51: 918-924.
  • 31.
    Tulubas F, Gurel A, Oran M, Topcu B, Caglar V, Uygur E. The protective effects of -3 fatty acids on doxorubicin-induced hepatotoxicity and nephrotoxicity in rats. Toxicol Ind Health 2015; 31: 638-644.
  • 32.
    Hirotani M, Ino C, Furuya T, Shiro M. Ganoderic acids T, S and R. New triterpenoids from the cultured mycelia of Ganoderma lucidum. Chem Pharm Bull 1986; 34: 2282-2285.##https://doi.org/10.1248/cpb.34.2282.
  • 33.
    Hossen M, Billah Prince M, Tanvir EM, Chowdhury M, Rahman M, Alam F, et al. Ganoderma lucidum and Auricularia polytricha mushrooms protect against Carbofuran-induced toxicity in rats. Evi Based Complement Alternat Med 2018; 2018.
  • 34.
    Susilo RJ, Winarni D, Husen SA, Hayaza S, Punnapayak H, Wahyuningsih SP, et al. Hepatoprotective effect of crude polysaccharides extracted from Ganoderma lucidum against carbon tetrachloride-induced liver injury in mice. Vet World 2019; 12: 1987.
comments

Leave a comment here

Share on
Metrics

Purchasing Reprints

  • Copyright Clearance Center (CCC) handles bulk orders for article reprints for Brieflands. To place an order for reprints, please click here (   https://www.copyright.com/landing/reprintsinquiryform/ ). Clicking this link will bring you to a CCC request form where you can provide the details of your order. Once complete, please click the ‘Submit Request’ button and CCC’s Reprints Services team will generate a quote for your review.
Search Relations

Author(s):

Related Articles