Diagnostic value of serum hepcidin and total bilirubin, and neutrophil to lymphocyte ratio in the diagnosis of acute appendicitis in children

authors:

avatar hosein asadi ORCID , avatar Mirsalim Seyed Sadeghi , * , avatar Negin Haghshenas , avatar Sanaz Karimi , avatar Hamed Zandian

Koomesh: Vol.25, issue 6; 654-658
published online: December 01, 2023
article type: Research Article
received: July 03, 2023
accepted: October 01, 2023

how to cite: asadi H, Seyed Sadeghi M, Haghshenas N, Karimi S, Zandian H. Diagnostic value of serum hepcidin and total bilirubin, and neutrophil to lymphocyte ratio in the diagnosis of acute appendicitis in children. koomesh. 2023;25(6):e152864. 

Abstract

Introduction: One of the most common causes of abdominal pain in children is acute appendicitis. This study aimed to determine the diagnostic value of serum hepcidin, total bilirubin and neutrophil to lymphocyte ratio in the diagnosis of acute appendicitis in children. Materials and Methods: This cross-sectional study was conducted on 87 patients aged 6 to 16 with acute abdominal and primary diagnosis of acute appendicitis in Fatemi Ardabil Hospital for 6 months. Laboratory indicators of bilirubin, neutrophil to lymphocyte ratio and, serum hepcidin level of patients were measured. Based on the results of the surgery, the patients were divided into two groups with appendicitis and without inflammation. Results: The mean serum hepcidin in the group with inflamed appendicitis was 33.63±5.84 and in the non-inflamed group it was 19.36±5.34. The average bilirubin in inflamed appendicitis was 1±0.54 and non-inflamed appendicitis was 0.74±0.29. The laboratory indicators of hepcidin, neutrophil, leukocyte, and the ratio of neutrophil to leukocyte were statistically significant in the two groups (P<0.001). The sensitivity of hepcidin was 47.1, the specificity 76.5, the positive predictive value 89.2, and the negative predictive value 26. Hyperbilirubinemia had a sensitivity of 41.4, a specificity of 82.4, a positive predictive value of 90.6, and a negative predictive value of 25.5. The ratio of neutrophils to lymphocytes had a sensitivity of 94.3, a specificity of 100, a positive predictive value of 100, and a negative predictive value of 80.9. Conclusion: Biomarkers level of total bilirubin, hepcidin, and neutrophil to lymphocyte ratio can be useful as clinical indicators in diagnosing complicated appendicitis in children.

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