Effect of carnosine on cerebral edema and oxidative stress biomarkers in a transient model of focal cerebral ischemia in rats

Abedin Vakili; Ahmad Reza Bandegi; Saeed Baiati; Roya Hassanzadeh; Yasin Asadi

Koomesh

Journal of Semnan University of Medical Sciences

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Effect of carnosine on cerebral edema and oxidative stress biomarkers in a transient model of focal cerebral ischemia in rats

Author(s):

Abedin Vakili

^,*,

Ahmad Reza Bandegi,

Saeed Baiati,

Roya Hassanzadeh,

Yasin Asadi

Koomesh:Vol. 15, issue 4; 493-501

Published online:Aug 28, 2014

Article type:Research Article

Received:Jul 01, 2013

Accepted:Dec 01, 2013

How to Cite:Abedin VakiliAhmad Reza BandegiSaeed BaiatiRoya HassanzadehYasin AsadiEffect of carnosine on cerebral edema and oxidative stress biomarkers in a transient model of focal cerebral ischemia in rats.koomesh.15(4):e152885.

Abstract

Introduction: Carnosine is an endogenous dipeptide expressed in many tissues including brain and has a protective effect against ischemic brain damage. However, its effect on brain edema, which is one of the most important variables in determining the amount of secondary brain damage after stroke, is not clear. The present study was conducted to investigate the effect of L-Carnosine on brain edema and oxidative stressbiomarkers in an experimental model of focal cerebral ischemia. Materials and Methods: Under Laser Doppler flowmetry, cerebral ischemia was induced by transient occlusion of middle cerebral artery for 1 hour in rats. L-Carnosine at doses of 250 and 500 mg/kg.ip was injected immediately after induction of ischemia. Cerebral edema and enzymes activity of superoxide dismutase (SOD), glutathione peroxidase (GPx) and malondialdehyde (MDA) content were measured 24 hours after ischemia using a standard method and kit. Results: Administration of L-Carnosine at doses 250(%81.5±0.36) and 500 (%80.9±0.30) mg/kg significantly reduced brain edema by 25% and 40% in comparison with the control group (%82.53±0.16), respectively (P

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