Effect of eight weeks resistance training and ginger supplementation on glycosylated hemoglobin index in type 2 diabetes patients

authors:

avatar Hamzeh Mohammadi , avatar Seyed Mohsen Avandi ORCID , * , avatar Masoud Jamshidi , avatar Mehrdad Gooya


how to cite: Mohammadi H, Avandi S M, Jamshidi M, Gooya M. Effect of eight weeks resistance training and ginger supplementation on glycosylated hemoglobin index in type 2 diabetes patients. koomesh. 2017;19(4):e152933. 

Abstract

Introduction: The aim of this study was to determine the effect of eight weeks resistance training and ginger consumption on Glycosylated hemoglobin index in type 2 diabetic. Materials and Methods: For this purpose in a semi-experimental design with double-blind, 44 type 2 diabetic patients (Fasting glucose ≥126mg.dl 40-60) (with average height 169.92±7.20 cm, weight 82.41±6.34 Kg, age 53.49±7.01 years and BMI 28.57±2.07 m2), randomly divided into four groups: ginger rhizome, resistance training plus placebo consumption, resistance training plus ginger rhizome and placebo. The subjects in Group GI+RT and GI received 1 gram of ginger capsule a day (zintoma) for eight weeks. Subjects of resistance training groups also carried out a progressive resistance protocol with 65 to 80 percent of 1RM for 8 weeks (Three times a week). Before and 48 hours after eight weeks of training, assessment of height, weight, body fat and BMI were taken. Glycosylated hemoglobin (Hba1c) Biosystems using ion-exchange chromatography using Dss Ingland was measured. Results: Glycosylated hemoglobin index and body fat after eight weeks of resistance training and Ginger supplementation in training groups had a significant difference, but the change was not observed in groups of ginger and placebo (p≥0.05). Conclusion: Finally on the basis of obtained results, the long-term consumption of ginger and resistance training can be an effective factor for favorable changes Glucose index type II diabetic patients in a long-term process.

References

  • 1.

    Arablou T, Aryaeian N, Valizadeh M, Hosseini A, Djalali M. The effect of ginger consumption on some cardiovascular risk factors in patients with type 2 diabetes mellitus. Razi J Med Sci 2014; 21: 1-12.

  • 2.

    Li Y, Tran VH, Duke CC, Roufogalis BD. Preventive and protective properties of Zingiber officinale (ginger) in diabetes mellitus, diabetic complications, and associated lipid and other metabolic disorders: a brief review. Evid Based Complement Alternat Med 2012; 2012: 516870.

  • 3.

    Goldman L, Schafer AI. Goldman's Cecil medicine: Elsevier Health Sciences; 2011.

  • 4.

    Poirier P, Dufour R, Carpentier A, Larose . Screening for the presence of coronary artery disease. Can J Diabetes 2013; 37: S105-S109.

  • 5.

    Gilanei-Taiba ME, Haghshenas R, Tahmina Saeedi ZM. The effect of 12 weeks of yoga classes on fasting glucose, glycosylated hemoglobin and lipid profile in patients with type 2 diabete. Volume 7, Issue 2. (Persian).

  • 6.

    Kahn R, Buse J, Ferrannini E, Stern M. The metabolic syndrome: time for a critical appraisal Joint statement from the American diabetes association and the European association for the study of diabetes. Diabetes Care 2005; 28: 2289-2304.

  • 7.

    Turner RC, Cull CA, Frighi V, Holman RR, Group UPDS. Glycemic control with diet, sulfonylurea, metformin, or insulin in patients with type 2 diabetes mellitus: progressive requirement for multiple therapies (UKPDS 49). JAMA 1999; 281: 2005-2012.

  • 8.

    Goodpaster FH, Brown FF. Skeletal muscle lipid and its association with insulin resistance: what is the role for exercise? Exerc Sport Sci Rev 2005; 33: 150-154.

  • 9.

    Martinus R, Corban R, Wackerhage H, Atkins S, Singh J. Effect of psychological intervention on exercise adherence in type 2 diabetic subjects. Ann N Y Acad Sci 2006; 1084: 350-360.

  • 10.

    Bacchi E, Negri C, Zanolin ME, Milanese C, Faccioli N, Trombetta M, et al. Metabolic effects of aerobic training and resistance training in type 2 diabetic subjects a randomized controlled trial (the RAED2 study). Diabetes Care 2012; 35: 676-682.

  • 11.

    Soori R, Rashidi M, Choobineh S, Ravasi AA, Baesi K, Rashidy-Pour A. Effects of 12 weeks resistant training on MTNR1B gene expression in the pancreas and glucose and insulin levels in type 2 diabetic rats. Koomesh 2017; 19: 46-55.

  • 12.

    Marcus RL, Smith S, Morrell G, Addison O, Dibble LE, Wahoff-Stice D, et al. Comparison of combined aerobic and high-force eccentric resistance exercise with aerobic exercise only for people with type 2 diabetes mellitus. Phys Ther 2008; 88: 1345-1354.

  • 13.

    Castaneda C, Layne JE, Munoz-Orians L, Gordon PL, Walsmith J, Foldvari M, et al. A randomized controlled trial of resistance exercise training to improve glycemic control in older adults with type 2 diabetes. Diabetes Care 2002; 25: 2335-2341.

  • 14.

    Dunstan DW, Daly RM, Owen N, Jolley D, De Courten M, Shaw J, et al. High-intensity resistance training improves glycemic control in older patients with type 2 diabetes. Diabetes Care 2002; 25: 1729-1736.

  • 15.

    Mahluji S, Attari VE, Mobasseri M, Payahoo L, Ostadrahimi A, Golzari SE. Effects of ginger (Zingiber officinale) on plasma glucose level, HbA1c and insulin sensitivity in type 2 diabetic patients. Int J Food Sci Nutr 2013; 64: 682-686.

  • 16.

    Ali BH, Blunden G, Tanira MO, Nemmar A. Some phytochemical, pharmacological and toxicological properties of ginger (Zingiber officinale Roscoe): a review of recent research. Food Chem Toxicol 2008; 46: 409-420.

  • 17.

    Madani P, Avandy SM, Haghshenas R, Pakdel A. Combined effect of eight weeks high intensity resistance training with ginger supplementation on waist to hip ratio, body composition and body mass in obese women. Koomesh 2017; 19: 289-293.

  • 18.

    Atashak S, Peeri M, Azarbayjani MA, Stannard SR. Effects of ginger (Zingiber officinale Roscoe) supplementation and resistance training on some blood oxidative stress markers in obese men. J Exerc Sci Fitness 2014; 12: 26-30.

  • 19.

    Ojewole JA. Analgesic, antiinflammatory and hypoglycaemic effects of ethanol extract of Zingiber officinale (Roscoe) rhizomes (Zingiberaceae) in mice and rats. Phytother Res 2006; 20: 764-772.

  • 20.

    Bordia A, Verma S, Srivastava K. Effect of ginger (Zingiber officinale Rosc.) and fenugreek (Trigonella foenumgraecum L.) on blood lipids, blood sugar and platelet aggregation in patients with coronary artery disease. Prostaglandins Leukot Essent Fatty Acids 1997; 56: 379-384.

  • 21.

    Aryaeian AA, %A Sharifi, %A Hosseini, %A Valizadeh. Effect of ginger consumption on glycemic status, insulin resistance, and inflammatory markers in patients with type 2 diabetes mellitus. Iran J Nutr Sci Food Technol 2014; 9: 1-10. (Persian).

  • 22.

    Atashak S, Peeri M, Azarbayjani M.A, Stephen R.Effects of ginger (Zingiber officinale Roscoe) supplementation and resistance training on some blood oxidative stress markers in obese men. ExeSci Fit. 2014; 12, 26-30 (Persian).

  • 23.

    Bobeuf F, Labonte M, Dionne I, Khalil A. Combined effect of antioxidant supplementation and resistance training on oxidative stress markers, muscle and body composition in an elderly population. J Nutr Health Aging 2011; 15: 883-889.

  • 24.

    Wells J, Fewtrell M. Measuring body composition. Arch Dis Child 2006; 91: 612-617.

  • 25.

    Cauza E, Hanusch-Enserer U, Strasser B, Kostner K, Dunky A, Haber P. The metabolic effects of long term exercise in Type 2 Diabetes patients. Wien Med Wochenschr 2006; 156: 515-519.

  • 26.

    Group UPDS. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet 1998; 352: 837-853.

  • 27.

    Khaw KT, Wareham N, Luben R, Bingham S, Oakes S, Welch A, et al. Glycated haemoglobin, diabetes, and mortality in men in Norfolk cohort of European prospective investigation of cancer and nutrition (EPIC-Norfolk). BMJ 2001; 322: 15-18.

  • 28.

    Maiorana A, O'Driscoll G, Goodman C, Taylor R, Green D. Combined aerobic and resistance exercise improves glycemic control and fitness in type 2 diabetes. Diabetes Res Clin Pract 2002; 56: 115-123.

  • 29.

    Zanuso S, Jimenez A, Pugliese G, Corigliano G, Balducci S. Exercise for the management of type 2 diabetes: a review of the evidence. Acta Diabetol 2010; 47: 15-22.

  • 30.

    Sigal RJ, Kenny GP, Boule NG, Wells GA, Prud'homme D, Fortier M, et al. Effects of aerobic training, resistance training, or both on glycemic control in type 2 diabetes: a randomized trial. Ann Intern Med 2007; 147: 357-369.

  • 31.

    Tessier D, Mnard J, Flp T, Ardilouze JL, Roy MA, Dubuc N, et al. Effects of aerobic physical exercise in the elderly with type 2 diabetes mellitus. Arch Gerontol Geriatr 2000; 31: 121-132.

  • 32.

    Cuff DJ, Meneilly GS, Martin A, Ignaszewski A, Tildesley HD, Frohlich JJ. Effective exercise modality to reduce insulin resistance in women with type 2 diabetes. Diabetes Care 2003; 26: 2977-2982.

  • 33.

    Talaei B, Mozaffari-Khosravi H, Jalali B, Mahammadi M, Najarzadeh A, Fallahzadeh H. The Effect of Ginger on Blood Glucose, Lipid and Lipoproteins in Patients with Type 2 Diabetes: A Double-Blind Randomized Clinical Controlled Trial. SSU 2012; 20: 383-395.

  • 34.

    Hasanvand B, Karami K, Khodadi A, Valipour M. Impact determination of strength and resistance training on Glycoside hemoglobin and blood sugar on patients with type II diabetes. Yafteh 2011; 13: 75-81.

  • 35.

    Kern M, Wells JA, Stephens JM, Elton CW, Friedman JE, Tapscott EB, et al. Insulin responsiveness in skeletal muscle is determined by glucose transporter (Glut4) protein level. Biochemical 1990; 270: 397-400.