Anti-proliferative effects of new synthesized hydrazone derivatives on breast, colon and hepatic cancer cells

authors:

avatar Mehrasa Shademani , avatar Nasrin Nassiri Koopaei , avatar Nasrin Shirzad Yazdi , avatar Homa Azizian , avatar Zahra Mousavi , avatar Mona Salimi , avatar Ali Almasirad , *

Koomesh: Vol.20, issue 4; 725-730
published online: August 07, 2018
article type: Research Article
received: February 10, 2017
accepted: May 07, 2018

how to cite: Shademani M, Nassiri Koopaei N, Shirzad Yazdi N, Azizian H, Mousavi Z, et al. Anti-proliferative effects of new synthesized hydrazone derivatives on breast, colon and hepatic cancer cells. koomesh. 2018;20(4):e153018. 

Abstract

Introduction: Despite the advances made in research on cancer, there is still no effective way to treat this condition. A number of compounds including hydrazone derivatives have been increasingly investigated as anticancer agents. So, in this study a series of novel hydrazone derivatives were designed and synthesized as potential anticancer compounds and their cytotoxic effects were further evaluated. Materials and Methods: The designed hydrazone compounds (1-9) were synthesized in three steps and their structures were characterized by different instrumental analysis methods. The cytotoxic activity was measured using MTT assay at 48 and 72 h on human breast, colon and liver cancer cell lines. Results: The obtained percentage of cytotoxicity indicated that some compounds were potent against cancer cell lines and the most effective incubation time was after 72 h of treeatment. Among the synthesized compounds, compounds 3 and 6 revealed the considerable cytotoxic activity on breast, liver and colon cells after 72 h of treatment ranging from 60 to 80%. Conclusion: The results obtained in this section can be used as the starting point for the development of new cancer chemotherapy agents

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