Koomesh
Journal of Semnan University of Medical Sciences
Outlines
Induction of apoptotic and anti-proliferative effects in REH cells upon neurokinin-1 receptor inhibition using Aprepitant
Author(s):
Published online:Mar 30, 2018
Article type:Research Article
Received:Nov 08, 2017
Accepted:Mar 01, 2018
How to Cite:Elham RazaniA. va Safaroghli-AzarDavood BashashInduction of apoptotic and anti-proliferative effects in REH cells upon neurokinin-1 receptor inhibition using Aprepitant.koomesh.20(4):e153022.
Abstract
References
- 1.Harrison CJ. Targeting signaling pathways in acute lymphoblastic leukemia: new insights. Hematology Am Soc Hematol Educ Program 2013; 2013: 118-125.
- 2.Hinze L, Mricke A, Zimmermann M, Junk S, Cario G, Dagdan E, et al. Prognostic impact of IKZF1 deletions in association with vincristinedexamethasone pulses during maintenance treatment of childhood acute lymphoblastic leukemia on trial ALL-BFM 95. Leukemia 2017; 31: 1840-1842.
- 3.Esteban F, Munoz M, Gonzalez-Moles M, Rosso M. A role for substance P in cancer promotion and progression: a mechanism to counteract intracellular death signals following oncogene activation or DNA damage. Cancer Metastasis Rev 2006; 25: 137-145.
- 4.Munoz M, Rosso M, Coveas R. The NK-1 receptor is involved in the antitumoural action of L-733,060 and in the mitogenic action of substance P on human pancreatic cancer cell lines. Lett Drug Design Discov 2006; 3: 323-329.
- 5.Akazawa T, Kwatra SG, Goldsmith LE, Richardson MD, Cox EA, Sampson JH, et al. A constitutively active form of neurokinin 1 receptor and neurokinin 1 receptormediated apoptosis in glioblastomas. J Neurochem 2009; 109: 1079-1086.
- 6.Munoz M, Rosso M, Prez A, Covenas R, Rosso R, Zamarriego C, et al. Antitumoral action of the neurokinin-1-receptor antagonist L-733,060 and mitogenic action of substance P on human retinoblastoma cell lines. Invest Ophthalmol Vis Sci 2005; 46: 2567-2570.
- 7.Muoz M, Gonzlez-Ortega A, Coveas R. The NK-1 receptor is expressed in human leukemia and is involved in the antitumor action of aprepitant and other NK-1 receptor antagonists on acute lymphoblastic leukemia cell lines. Invest New Drugs 2012; 30: 529-540.
- 8.Grassin-Delyle S, Buenestado A, Vallat L, Naline E, Marx S, Decocq J, et al. Expression and proliferative effect of hemokinin-1 in human B-cells. Peptides 2011; 32: 1027-1034.
- 9.Quartara L, Altamura M, Evangelista S, Maggi CA. Tachykinin receptor antagonists in clinical trials. Expert Opin Investig Drugs 2009; 18: 1843-1864.
- 10.Aapro M, Carides A, Rapoport BL, Schmoll H-J, Zhang L, Warr D. Aprepitant and fosaprepitant: a 10-year review of efficacy and safety. Oncologist 2015; 20: 450-458.
- 11.Muoz M, Rosso M. The NK-1 receptor antagonist aprepitant as a broad spectrum antitumor drug. Invest New Drugs 2010; 28: 187-193.
- 12.Muoz M, Gonzlez-Ortega A, Salinas-Martn MV, Carranza A, Garcia-Recio S, Almendro V, et al. The neurokinin-1 receptor antagonist aprepitant is a promising candidate for the treatment of breast cancer. Int J Oncol 2014; 45: 1658-1672.
- 13.Nakade S, Ohno T, Kitagawa J, Hashimoto Y, Katayama M, Awata H, et al. Population pharmacokinetics of aprepitant and dexamethasone in the prevention of chemotherapy-induced nausea and vomiting. Cancer Chemother Pharmacol 2008; 63: 75-83.
- 14.Kast RE, Ramiro S, Llad S, Toro S, Coveas R, Muoz M. Antitumor action of temozolomide, ritonavir and aprepitant against human glioma cells. J Neurooncol 2016; 126: 425-431.
- 15.Garnier A, Ilmer M, Kappler R, Berger M. Therapeutic Innovations for Targeting Hepatoblastoma. Anticancer Res 2016; 36: 5577-5592.
- 16.Garnier A, Vykoukal J, Hubertus J, Alt E, Von Schweinitz D, Kappler R, et al. Targeting the neurokinin-1 receptor inhibits growth of human colon cancer cells. Int J Oncol 2015; 47: 151-160.
- 17.Muoz M, Coveas R. Neurokinin-1 receptor antagonists as antitumor drugs in gastrointestinal cancer: A new approach. Saudi J Gastroenterol 2016; 22: 260-268.
- 18.Muoz M, Berger M, Rosso M, Gonzalez-Ortega A, Carranza A, Coveas R. Antitumor activity of neurokinin-1 receptor antagonists in MG-63 human osteosarcoma xenografts. Int J Oncol 2014; 44: 137-146.
- 19.Bayati S, Bashash D, Ahmadian S, Safaroghli-Azar A, Alimoghaddam K, Ghavamzadeh A, et al. Inhibition of tachykinin NK 1 receptor using aprepitant induces apoptotic cell death and G1 arrest through Akt/p53 axis in pre-B acute lymphoblastic leukemia cells. Eur J Pharmacol 2016; 791: 274-283.
- 20.Bayati S, Razani E, Bashash D, Safaroghli-Azar A, Safa M, Ghaffari SH. Antileukemic effects of neurokinin-1 receptor inhibition on hematologic malignant cells: a novel therapeutic potential for aprepitant. Anticancer Drugs 2018; 29: 243-252.
- 21.Kryvenko ON, Williamson SR, Trpkov K, Gupta NS, Athanazio D, Selig MK, et al. Small cell-like glandular proliferation of prostate: a rare lesion not related to small cell prostate cancer. Virchows Arch 2017; 470: 47-54.
Copyright
© 2018, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
comments
Leave a comment here
Comments
Number of Comments:0Purchasing Reprints
- Copyright Clearance Center (CCC) handles bulk orders for article reprints for Brieflands. To place an order for reprints, please click here ( https://www.copyright.com/landing/reprintsinquiryform/ ). Clicking this link will bring you to a CCC request form where you can provide the details of your order. Once complete, please click the ‘Submit Request’ button and CCC’s Reprints Services team will generate a quote for your review.
Search Relations
Author(s):
Related Articles