Predictive value of transcutaneous bilirubinometry on third day of birth in diagnosis of hyperbilirubinemia in term and near-term neonates

authors:

avatar Maryam Hasani , avatar Ashraf Ghiasi , avatar Masoumeh Kheirkhah , * , avatar Maryam Sabuteh , avatar Zahra Karimian , avatar Hamideh Zaheri , avatar Hanieh Abbasinia


how to cite: Hasani M, Ghiasi A, Kheirkhah M, Sabuteh M, Karimian Z, et al. Predictive value of transcutaneous bilirubinometry on third day of birth in diagnosis of hyperbilirubinemia in term and near-term neonates. koomesh. 2019;21(1):e153032. 

Abstract

Introduction: Severe hyperbilirubinemia may cause side effects such as hearing impairment or bilirubin encephalopathy. In this way, transcutaneous bilirubinometry (TCB) is a non-invasive screening method, which is performed using BiliCheck and does not require frequent blood sampling, time and cost. The aim of this study was to determine the predictive value of TCB on third day of birth in neonatal hyperbilirubinemia diagnosis in term and near-term neonates. Materials and Methods: A test assessment method was chosen with continuous sampling in 388 neonates 35 weeks and more at AkabarAbadi hospital in Tehran in 2011. On the third day of birth, cutaneous bilirubin levels (TCB) in the forehead by using BiliCheck and serum bilirubin (TSB) was measured from the heel capillary sample and consequently were compared with each other. Results: In neonatal hyperbilirubinemia diagnosis on the third day of birth, cutaneous bilirubin measurement had the sensitivity of 82% with the confidence interval (78.2%, 85.7%), specificity of 99.3% with the confidence interval (98.7%, 99.9%), positive predictive value of 92.9 with the confidence interval (88.0%, 96.2%) and negative predictive value of 94.8% with the confidence interval (92.8, 96.8). Generally, the third day measurement of cutaneous bilirubin had a predictive value of 94.5% in detecting high-risk neonates for hyperbilirubinemia. Conclusion: Third day TCB, in addition to being non-invasive and convenient use, has a high predictive value to detecting the risk of hyperbilirubinemia in neonate and it is recommended to use hyperbilirubinemia screening

References

  • 1.

    Martin RJ, Fanaroff AA, Walsh MC. Fanaroff and Martin's neonatal-perinatal medicine: diseases of the fetus and infant: Elsevier Health Sciences; 2010.

  • 2.

    Newman TB, Liljestrand P, Escobar GJ. Combining clinical risk factors with serum bilirubin levels to predict hyperbilirubinemia in newborns.Arch Pediatr Adolesc Med 2005; 159:113.

  • 3.

    Bolbol-Haghighi N, Masoumi SZ, Kazemi F.Effect of continued support of midwifery students in labour on the childbirth and labour consequences: arandomized controlled clinical trial. J Clin Diagn Res 2016; 10:QC14.

  • 4.

    Bhutani VK, Johnson L. Prevention of severe neonatal hyperbilirubinemia in healthy infants of 35 or more weeks of gestation: implementation of a systems-based approach. J Pediatr 2007; 83:289-293.

  • 5.

    Rostami N, Shahverdizadeh M. Determining the diagnostic power of transcutaneous bilirubinometry (TCB). J Research in Medicine. 2007;31:351-3.

  • 6.

    American Academy of Pediatrics Subcommittee on Hyperbilirubinemia.Management of hyperbilirubinemia in the newborn infant 35 or more weeks of gestation. Pediatrics 2004; 114:297.

  • 7.

    Bhutani VK, Johnson LH, Keren R. Diagnosis and management of hyperbilirubinemia in the term neonate: for a safer first week. Pediatr Clin 2004; 51:843-861.

  • 8.

    Martnez JC. International perspectives: neonatal jaundice: building a culture of safety (an argentinean perspective). Neo Rev 2012; 13:e77-e80.

  • 9.

    Soorani-Lunsing I, Woltil HA, Hadders-Algra M. Are moderate degrees of hyperbilirubinemia in healthy term neonates really safe for the brain? Pediatr Res 2001; 50:701-705.

  • 10.

    Mokhtari Amir Majdi N, Boskabadi H, Khalesi H. Evaluation of auditory brainstem response (ABR) in neonatal hyperbilirubinemia. Iran J Otorhinolaryngology 2008; 20:27-32.(Persian).

  • 11.

    Nabavi S, Behzad Moghadam M, Arab Hosseini M, Vaezi M, Rajabi R. Evaluation of auditory brainstem responses (ABR) in healthy term infants with elevated bilirubin levels requiring exchange transfusion. ZUMS J 2011; 19:77-83. (Persian).

  • 12.

    Maisels MJ, Bhutani VK, Bogen D, Newman TB, Stark AR, Watchko JF. Hyperbilirubinemia in the newborn infant 35 weeks gestation: an update with clarifications. Pediatrics 2009; 124:1193-1198.

  • 13.

    Imani M, Mohammadi M. Comparison of change pattern of serum and transcutaneous bilirubin in hyper bilirubinemic neonates. 2004. (Persian).

  • 14.

    Carceller-Blanchard A, Cousineau J, Delvin E. Point of care testing: transcutaneous bilirubinometry in neonates. Clin Biochem 2009; 42:143-149.

  • 15.

    Kasiri KA, Nourbakhsh SM, Boroujeni TK, Khoshdel A. Correlation of transcutaneous and serum bilirubin levels in infants with neonatal jaundice hospitalized in Hajar Hospital in Shahrekord. Pajoohandeh J 2013; 18:189-194. (Persian).

  • 16.

    Boo NY, Ishak S. Prediction of severe hyperbilirubinaemia using the Bilicheck transcutaneous bilirubinometer. J Paediatr Child Health 2007;43:297-302.

  • 17.

    Samanta S, Tan M, Kissack C, Nayak S, Chittick R, Yoxall C. The value of Bilicheck as a screening tool for neonatal jaundice in term and nearterm babies. Acta Paediat 2004; 93:1486-1490.

  • 18.

    Kolman KB, Mathieson KM, Frias C. A comparison of transcutaneous and total serum bilirubin in newborn Hispanic infants at 35 or more weeks of gestation.J Am Board Fam Med 2007; 20:266-271.

  • 19.

    Mansouri M, Mahmoodnejad A, Taghizadeh Sarvestani R, Gharibi F. A comparison between transcutaneous bilirubin (TcB) and total serum bilirubin (TSB) measurements in term neonates. Int J Pediatr 2015; 3:633-641.

  • 20.

    Mahram M, Oveisi S, Jaberi N. Trans-Cutaneous Bilirubinometery versus serum bilirubin in neonatal jaundice. Acta Med Iran 2015; 53: 764-769.

  • 21.

    Sanpavat S, Nuchprayoon I, Smathakanee C, Hansuebsai R. Nomogram for prediction of the risk of neonatal hyperbilirubinemia, using transcutaneous bilirubin. J Med Assoc Thai 2005; 88:1187-1193.

  • 22.

    Afjeh A, Fallahi M, Jahanbeen M, Basiri A, Allaee M. Pre-discharge screening trans-cutaneous bilirubinometry in healthy newborns in Mahdieh hospital, Tehran. IranJ Pediatr 2015; 25: e2187.

  • 23.

    Gupta B, Chaudhary N, Bhatia B, Gupta B. Non invasive trans-cutaneous bilirubin as a screening test to identify the need for serum bilirubin assessment in healthy term neonates. J Univ College Med Sci 2014; 1:17-21.

  • 24.

    El-Beshbishi SN, Shattuck KE, Mohammad AA, Petersen JR. Hyperbilirubinemia and transcutaneous bilirubinometry. Clin Chem 2009; 55:1280-1287.

  • 25.

    De Luca D, Zecca E, De Turris P, Barbato G, Marras M, Romagnoli C. Using BiliCheck for preterm neonates in a sub-intensive unit: Diagnostic usefulness and suitability. Early Hum Dev 2007; 83:313-317.

  • 26.

    Mohamed I, Blanchard A, Delvin E, Cousineau J, Carceller A. Plotting transcutaneous bilirubin measurements on specific transcutaneous nomogram results in better prediction of significant hyperbilirubinemia in healthy term and near-term newborns: a pilot study. Neonatology 2014; 105:306-311.

  • 27.

    Rasoolyneghad A, Amin Beidokhti M, Rashidy-Pour A, Ghorbany R. Estimation of hyperbilirubinemia by observation of neonate skin withjaundice in Amiralmomenin's hospital of Semnan, 1999. Koomesh 2000; 1:29-33. (Persian)##.