Plasma levels of omentin in patients with medullary thyroid carcinoma

Fatemeh Norasti; Marjan Zarif Yeganeh; Sara Sheikholeslami; Laleh Hoghooghi Rad; Hoda Golab Ghadaksaz; Mehdi Hedayati

Koomesh

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Plasma levels of omentin in patients with medullary thyroid carcinoma

Author(s):

Fatemeh Norasti,

Marjan Zarif Yeganeh,

Sara Sheikholeslami,

Laleh Hoghooghi Rad,

Hoda Golab Ghadaksaz,

Mehdi Hedayati

^,*

Koomesh:Vol. 21, issue 1; 83-86

Published online:Mar 09, 2019

Article type:Research Article

Received:Sep 05, 2017

Accepted:Jun 09, 2018

How to Cite:Fatemeh NorastiMarjan Zarif YeganehSara SheikholeslamiLaleh Hoghooghi RadHoda Golab GhadaksazMehdi Hedayatiet al.Plasma levels of omentin in patients with medullary thyroid carcinoma.koomesh.21(1):e153041.

Abstract

Introduction: Medullary thyroid carcinoma (MTC) accounts for 5- 10% of thyroid malignancies. The origin of medullary thyroid cancer is para-follicular cells of the thyroid. Several studies showed that relationship between adipokines and cancers. Omentin is an adipokine secreted from adipose tissue. The aim of this study was to investigate the relationship between plasma levels of omentin in patients with medullary thyroid cancer. Materials and Methods: In this case-control study, 90 individuals were studied (45 cases and 45 controls). Omentin plasma levels of these individuals were measured by ELISA method. Results: In general, plasma levels of omnentin in all patients with MTC was significantly higher than the control group (P = 0.002). Omentin plasma levels in both women and men with MTC were ignificantly higher than the corresponding control group (P = 0.0371, and P = 0.0240, respectively). Conclusion: The results of this study showed that plasma levels omentin in patients with MTV were higher than the healthy group. Thus omentin may be considered as a novel and promising biomarker for diagnosis or confirmation of MTC.

Keywords

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