Correlation between serum levels of RANKL with osteoporosis in patients with beta thalassemia major

Fatemeh Jafari; Azita Azarkeivan; Davod Bashash; Ali Akbar Khadem Maboodi; mohsen hamidpour

Koomesh

Journal of Semnan University of Medical Sciences

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Correlation between serum levels of RANKL with osteoporosis in patients with beta thalassemia major

Author(s):

Fatemeh Jafari,

Azita Azarkeivan,

Davod Bashash,

Ali Akbar Khadem Maboodi,

mohsen hamidpour

^,*

Koomesh:Vol. 21, issue 1; 150-154

Published online:Mar 05, 2019

Article type:Research Article

Received:Apr 02, 2018

Accepted:Sep 05, 2018

How to Cite:Fatemeh JafariAzita AzarkeivanDavod BashashAli Akbar Khadem Maboodimohsen hamidpourCorrelation between serum levels of RANKL with osteoporosis in patients with beta thalassemia major.koomesh.21(1):e153051.

Abstract

Introduction: Osteoporosis is a major problem in patients with B-thalassemia major. Osteoclasts hyperactivity, which increases serum levels of receptor activator of nuclear factor kappa-Β ligand (RANKL), plays an important role in the pathogenesis of osteoporosis in these patients. The aim of this study was to study the relationship between serum levels of RANKL and osteoporosis in patients with beta thalassemia major. Materials and Methods: 52 patients with beta thalassemia major and 22 people with thalassemia minor without any osteoporosis symptoms as controls were entered the study. Six ml of peripheral blood was obtained for hematologic and serum RANKL measurements. Results: The mean of bone mineral density in patients were 0.57 ± 0.3 and 0.69 ± 0.11 in femur and vertebra, respectively. There were significant differences between hematologic parameters of patients and controls. The mean of patient’s serum RANKL level was 198.4pg/mL and in controls was 112.25pg/mL. There was a correlation between decrease of femur BMD (p

Keywords

B- Thalassemia Major

Osteoporosis

Hematologic Parameters

RANKL

بتاتالاسمی ماژور

استئوپورزیس

پارامترهای هماتولوژیک

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