Performance of methylation and expression fluctuations of sonic hedgehog genes in gastric adenocarcinoma

authors:

avatar Ali Akbar Samadani ORCID , * , avatar Fariborz Mansour-Ghanaie , avatar Farahnaz Joukar , avatar Mahsa Safizadeh , avatar Seyedeh Elham Nourollahi , avatar A. li Rashidy-Pour

Koomesh: Vol.21, issue 2; 215-224
published online: March 01, 2019
article type: Research Article
received: September 04, 2018
accepted: September 01, 2018

how to cite: Samadani A A, Mansour-Ghanaie F, Joukar F, Safizadeh M, Nourollahi S E, et al. Performance of methylation and expression fluctuations of sonic hedgehog genes in gastric adenocarcinoma. koomesh. 2019;21(2):e153060. 

Abstract

Gastric cancer (GC) is considered as one of the most serious cancers, and in Iran, due to environmental factors in different regions, it has a high frequency. Apart from environmental factors, genetic and epigenetic ones also play a key role in the development of carcinogenesis of GC. In this regard, the study of functioning of the molecular mechanisms involved in the carcinogenesis and also tumorigenesis of this malignancy in different molecular pathways   to identify applied biomarkers in early diagnosis is of great importance. Thus, molecular pathways like sonic hedgehog  (SHH) may interfere with this type of cancer. In this review, it has attempted to investigate the performance of the fluctuations of these important genes in SHH pathway.

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