Effects of central amygdala GABA-B on expression of morphine-induced sensitivity in female rats

How to Cite:firoozeh alavianHedayat SahraeiSaeedeh GhiasvandEffects of central amygdala GABA-B on expression of morphine-induced sensitivity in female rats.koomesh.21(2):e153080.

Abstract

Introduction: Dependence on morphine and its complications are considered as a major health problem in the world however, efforts to overcome this problem have failed due to the severity of drug dependence. Amygdala core nucleus (CeA) is one of the most important areas affecting the effects of morphine rewards. The GABAergic system in this nucleus especially the GABAB receptors plays an important role in modulating the morphine;#39s euphoric effects. In this study, the effects of intra-CeA injection of baclofen (GABAB receptor agonist) and CGP35348 (GABAB receptor antagonist) were studied on morphine sensitivity expression by conditioned place preference (CPP). Materials and Methods: Five days after surgery, different doses of morphine (0.5, 1, 2, 2.5, 5, 7.5 and 10 mg/kg) were administered subcutaneously (S.C) to determine the effective and ineffective dosages of morphine. Importantly, in order to induce sensitivity, the effective dose of morphine (7.5 mg/kg) was injected once daily for 3 days followed by 5 days’ rest, and on the 9th day, the CPP was started with the ineffective dose of morphine (2.5 mg/kg). Doses of 1.5, 6 and 12 μg/rat of baclofen and CGP35348 were injected into the CeA, 10 minutes before the CPP test. Results: Both agonist and antagonist significantly reduced the expression of morphine sensitivity in the female rats. Conclusion: GABA-B receptors within the CeA may interfere with the conditioned place preference expression of morphine sensitive female rats. It is possible that these receptors could be used as drug abuse goals.

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References

1.
Kim J, Ham S, Hong H, Moon C, Im HI. Brain reward circuits in morphine addiction. Mol Cells 2016; 39: 645-653.
2.
Alavian F, Ghiasvand S, Sahraei H, Rafiei-Rad M. Intervention of the Gamma-Aminobutyric acid type B receptors of the amygdala central nucleus on the sensitivity of the morphine-induced conditionally preferred location in wistar female rats. Addict Health 2017; 9: 110-117.
3.
Tritsch NX, Granger AJ, Sabatini BL. Mechanisms and functions of GABA co-release. Nat Rev Neurosci 2016; 17: 139-145.
4.
Vassoler FM, Wright SJ, Byrnes EM. Exposure to opiates in female adolescents alters mu opiate receptor expression and increases the rewarding effects of morphine in future offspring. Neuropharmacology 2016; 103: 112-121.
5.
Alavian F, Ghiasvand S. GABAB receptors within the central nucleus of amygdala may involve in the morphine-induced incentive tolerance in female rats. Iran J Basic Med Sci 2017; 20: 822-828.
6.
Rashidy-Pour A, Vafaei AA. The effect s of muscimol injection into basolateral amygdala on spatial memory processing in place avoidance learning task. Koomesh 2001; 2: 73-81. (Persian).
7.
Fields HL, Margolis EB. Understanding opioid reward. Trends Neurosci 2015; 38: 217-225.
8.
Mohammadian Z, Sahraei H, Meftahi GH, Ali-Beik H. Effects of unilatral and bilateral inhibition of rostral ventral tegmental area and central nucleus of amygdala on morphine-induced place conditioning in male Wistar rat. Clin Exp Pharmacol Physiol 2017; 44: 403-412.
9.
Crossman AR, Neary D. Neuroanatomy E-Book: An Illustrated Colour Text: Elsevier Health Sciences; 2014.
10.
Sahraei H, Amiri YA, Haeri-Rohani A, Sepehri H, Salimi SH, Pourmotabbed A, et al. Different effects of GABAergic receptors located in the ventral tegmental area on the expression of morphine-induced conditioned place preference in rat. Eur J Pharmacol 2005; 524: 95-101.
11.
Hiroi N, White NM. The lateral nucleus of the amygdala mediates expression of the amphetamine-produced conditioned place preference. J Neurosci 1991; 11: 2107-2116.
12.
Chalabi-Yani D, Sahraei H, Meftahi GH, Hosseini SB, Sadeghi-Gharajehdaghi S, Beig HA, et al. Effect of transient inactivation of ventral tegmental area on the expression and acquisition of nicotine-induced conditioned place preference in rats. Iran Biomed J 2015; 19: 214-219.
13.
Mirnajafi-Zadeh J, Sheibani V, Palizvan MR, Sadegh M, Zeinali T. The role of GABAA receptor activity in post-ictal depression period in a rat kindling model of epilepsy. Koomesh 2009; 10: 85-94. (Persian).
14.
Razavi Y, Katebi N, Zeighamy Alamdary s, Oryan S, Khodagholi F, Haghparast A. Changes in apoptotic factors caspase-3, PARP and Bax/Bcl-2 ratio in the ventral tegmental area after the acquisition and extinction of morphine-induced conditioned place preference in the rat. Koomesh 2013; 14: 404-413. (Persian).
15.
Davis M, Rainnie D, Cassell M. Neurotransmission in the rat amygdala related to fear and anxiety. Trends Neurosci 1994; 17: 208-214.
16.
Roberto M, Madamba SG, Moore SD, Tallent MK, Siggins GR. Ethanol increases GABAergic transmission at both pre-and postsynaptic sites in rat central amygdala neurons. Proc Natl Acad Sci U S A 2003; 100: 2053-2058.
17.
Rafieirad M, Sahraei H, Haeri RS, Sepehri H, Alavian DS, Ghoshouni H, Nourouzzadeh A. The modulatory role of Gaba-B receptors of the shell part of nucleus accumbens in the acquisition and expression of morphine-induced conditioned place preference in morphine-sensitized rats. Physiol Pharmacol 2007; 11: 182-191. (Persian).
18.
Sahraei H, Etemadi L, Rostami P, Pourmotabbed A, Zarrindast MR, Shams J, et al. GABA B receptors within the ventral tegmental area are involved in the expression and acquisition of morphine-induced place preference in morphine-sensitized rats. Pharmacol Biochem Behav 2009; 91: 409-416.
19.
Karami M, Zarrindast MR, Sepehri H, Sahraei H. Role of nitric oxide in the rat hippocampal CA1 area on morphine-induced conditioned place preference. Eur J pharmacol 2002; 449: 113-119.
20.
Haghparast A, Moaddab M, Ebrahimzadeh-Sarvestani M, Kermani M. Effects of reversible inactivation of the ventral tegmental area on the firing rate of neurons in the shell sub-region of the nucleus accumbens and on morphine-induced conditioned place preference in the rat. Koomesh 2012; 13: 189-200. (Persian).
21.
Mobasher M, Sahraei H, Sadeghi-Rad B, Kamalinejad M, Shams J. The effects of crocus sativus extract on the acquisition and expression of morphine-induced conditioned place preference in mice. J Rafsanjan Univ Med Sci 2006; 5: 143-150. (Persian).
22.
Rahimi, MA. A review on the prevalence and the patterns of drug abuse in women in Iran. Soc Welfare 2004; 3: 203-226.
23.
Tzschentke TM. Measuring reward with the conditioned place preference paradigm: a comprehensive review of drug effects, recent progress and new issues. Prog Neurobiol 1998; 56: 613-672.
24.
McBride WJ, Murphy JM, Ikemoto S. Localization of brain reinforcement mechanisms: intracranial self-administration and intracranial place-conditioning studies. Behav Brain Res 1999; 101: 129-152.
25.
Paxinos G, Franklin KBJ. The mouse brain in stereotaxic coordinates: Gulf Professional Publishing; 2004.
26.
Sadeghi-Gharajehdaghi S, Sahraei H, Bahari Z, Meftahi GH, Jahromi GP, Ali-Beik H. Effect of amygdaloid complex inhibition on nicotine-induced conditioned place preference in rats. J Appl Pharmace Sci 2017; 7: 040-47. (Persian0.
27.
Lutz P-E, Kieffer BL. Opioid receptors: distinct roles in mood disorders. Trends Neurosci 2013; 36: 195-206.
28.
Fattore L, Fadda P, Antinori S, Fratta W. Role of opioid receptors in the reinstatement of opioid-seeking behavior: an overview. Methods Mol Biol 2015: 281-293.
29.
Carroll ME, Lynch WJ, Roth ME, Morgan AD, Cosgrove KP. Sex and estrogen influence drug abuse. Trends Pharmacol Sci 2004; 25: 273-279.
30.
Haghparast A, Moaddab M, Ebrahimzadeh-Sarvestani M, Kermani M. Effects of reversible inactivation of the ventral tegmental area on the firing rate of neurons in the shell sub-region of the nucleus accumbens and on morphine-induced conditioned place preference in the rat. Koomesh 2012; 13: 189-200. (Persian).
31.
Herz A. Opioid reward mechanisms: a key role in drug abuse? Can J Physiol Pharmacol 1998; 76: 252-258.
32.
Xi ZX, Stein EA. GABAergic mechanisms of opiate reinforcement. Alcohol Alcohol 2002; 37: 485-494.
33.
Crow JM. Biomedicine: Move over, morphine. Nature 2016; 535: S4-S6.
34.
Vanderschuren LJ, Tjon GH, Nestby P, Mulder AH, Schoffelmeer AN, De Vries TJ. Morphine-induced long-term sensitization to the locomotor effects of morphine and amphetamine depends on the temporal pattern of the pretreatment regimen. Psychopharmacology 1997; 131: 115-122.
35.
Veinante P, Yalcin I, Barrot M. The amygdala between sensation and affect: a role in pain. J Mol Psychiatry 2013; 1: 9.
36.
Woo SH, Kim HS, Yun JS, Lee MK, Oh KW, Seong YH, et al. Inhibition of baclofen on morphine-induced hyperactivity, reverse tolerance and postsynaptic dopamine receptor supersensitivity. Pharmacol Res 2001; 43: 335-340.
37.
Leite-Morris KA, Fukudome EY, Shoeb MH, Kaplan GB. GABAB receptor activation in the ventral tegmental area inhibits the acquisition and expression of opiate-induced motor sensitization. J Pharmacol Exp Ther 2004; 308: 667-678.
38.
Bettler B, Kaupmann K, Mosbacher J, Gassmann M. Molecular structure and physiological functions of GABA B receptors. Physiol Rev 2004; 84: 835-867.
39.
Macey DJ, Froestl W, Koob GF, Markou A. Both GABA B receptor agonist and antagonists decreased brain stimulation reward in the rat. Neuropharmacology 2001; 40: 676-685.
40.
Kobrin KL, Moody O, Arena DT, Moore CF, Heinrichs SC, Kaplan GB. Acquisition of morphine conditioned place preference increases the dendritic complexity of nucleus accumbens core neurons. Addic Biol 2016; 21: 1086-1096.
41.
Amantea D, Tessari M, Bowery NG. Reduced G-protein coupling to the GABA B receptor in the nucleus accumbens and the medial prefrontal cortex of the rat after chronic treatment with nicotine. Neurosci Lett 2004; 355: 161-164.
42.
Kudo T, Konno K, Uchigashima M, Yanagawa Y, Sora I, Minami M, Watanabe M. GABA ergic neurons in the ventral tegmental area receive dual GABA/enkephalinmediated inhibitory inputs from the bed nucleus of the stria terminalis. Eur J Neurosci 2014; 39: 1796-1809.
43.
Nuss P. Anxiety disorders and GABA neurotransmission: a disturbance of modulation. Neuropsychiatr Dis Treat 2015; 11: 165-175.
44.
Becker JB, Hu M. Sex differences in drug abuse. Front Neuroendocrinol 2008; 29: 36-47.
45.
Loyd DR, Murphy AZ. Sex differences in the anatomical and functional organization of the periaqueductal grayrostral ventromedial medullary pathway in the rat: a potential circuit mediating the sexually dimorphic actions of morphine. J Comp Neurol 2006; 496: 723-738.
46.
Harris GC, Aston-Jones G. Enhanced morphine preference following prolonged abstinence: association with increased Fos expression in the extended amygdala. Neuropsychopharmacology 2003; 28: 292-299.
47.
Harrod SB, Mactutus CF, Bennett K, Hasselrot U, Wu G, Welch M, Booze RM. Sex differences and repeated intravenous nicotine: behavioral sensitization and dopamine receptors. Pharmacol Biochem Behav 2004; 78: 581-592##.

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