Synergic effects of Summer Savory extract and aspirin on human platelets function

authors:

avatar Mahya sadat Yasini , avatar Mohsen Hamidpour , * , avatar Abdolmajid Ayatolahi , avatar Masoud Shahmehri , avatar Nasrin Kehanpour

Koomesh: Vol.21, issue 3; 503-508
published online: July 02, 2019
article type: Research Article
received: November 01, 2017
accepted: July 02, 2018

how to cite: Yasini M S, Hamidpour M, Ayatolahi A, Shahmehri M, Kehanpour N. Synergic effects of Summer Savory extract and aspirin on human platelets function. koomesh. 2019;21(3):e153098. 

Abstract

Introduction: Cardiovascular disease is one of the most common diseases in the world. In this account, atherosclerosis is one of the main cause’s heart attacks. Coagulation activity of platelets plays an important role in atherosclerotic plaque formation, thrombosis formation and cardiovascular diseases. Aspirin is the most commonly drugs which used as anti-platelet function to prevent and treat cardiovascular diseases. Long-term using of aspirin sometimes has irreparable consequences, resulting in medicine doctors, have been recommended using of herbal medicine as a complementary drug. The present study was aimed to investigate the effect of Summer savory extract and aspirin on platelets function. Materials and Methods: Platelets were prepared from male healthy volunteers. The platelets were treated with concentrations (250-1000 µg/ml) of Summer savory extraction and aspirin (0.31 – 1.26 µg/ml) to investigate platelet function. We applied aggregometry test to determine platelet aggregation and ELISA assay to determine platelet adhesion and protein secretion. Results: The extract of Summer Savory at a concentration of 1000 µg/ml alone inhibited the platelets acvitity by 73%, and at a concentration of 500 µg/ml and with aspirin at a concentration of 0.63 µg/ml inhibited platelets function by 52% than control (P< 0.001). Conclusion: Considering the synergic antiplatelet effects of Summer Savory extract and aspirin, it is recommended to use this extract as an appropriate anti-platelet supplement with a low dose of aspirin for cardiac patients.  

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