The effect of topically applied water extract of Rhazya stricta on cutaneous wound healing in rats

authors:

avatar MohammadReza Khaksari , * , avatar MohammadEbrahim Rezvanni , avatar MohmmadAli Sajaddi , avatar Abbas Soleimani

Koomesh: Vol.1, issue 3; 1-10
published online: April 15, 2000
article type: Research Article

how to cite: Khaksari M, Rezvanni M, Sajaddi M, Soleimani A. The effect of topically applied water extract of Rhazya stricta on cutaneous wound healing in rats. koomesh. 2000;1(3):e153100. 

Abstract

Introduction. Rhazya stricta is used traditionally by kerman selimani tribes , to accelerte wound healing. The aim of this study was to evaluate the effect of topi cal application of water extract of Rhazya stricta on cutaneous wound healing and compare its effect with phenytoin cream. Materials and Methods. This interventional-experimental study performed on the three groups of adult male rats. Afte r anaesthesia, full thichness skin of upper dorsal part of the rats removed in 3 em' area. 24 hours afte r the operation, wound of each group treated once daily with water extract of R stricta or phenytoin cream (1%). Control group received no treatment. Wound surface area measured in 0, 4th, 7th, 10th, 13th, and 16th postoperative days. The time required for complete healing was also recorded. Results. The results show that wound surface area in R stricta gro up in l Oth day (60%) and in 13th day (77%) was lower than control group (P < 0.05). Percentage of wound healing in control group in 4th day (20%) and in 7th day (38%) was higher than R Stricta group (P