Rapid repair of skin ulcers in diabetic rats using polycaproplactone /gelatin nanon-fiber scaffold

How to Cite:Fariba ZafariMorteza SadeghiMehrdad Bakhtiyarishahram teimourianRapid repair of skin ulcers in diabetic rats using polycaproplactone /gelatin nanon-fiber scaffold.koomesh.21(3):e153113.

Abstract

Introduction: Three-dimensional nano scaffolds by creating a three-dimensional structure similar to the body tissues have created a new perspective on cell culture and tissue repair. The aim of this study was to investigate the effect of polycaprolactone biodegradation scaffold (PCL) in treatment of diabetic wounds. Materials and Methods: Nano PCL-Gelatine scaffold was synthesized by electrospun method. A circular wound (6 mm) was created in skin of 15 BALB/c rats and the rats were divided into 3 groups including: Non-diabetic group (sham), Diabetic group without nano scaffold receiving (control) and diabetic group with nano scaffolds (scaffold). Wound surface area and wound healing were evaluated on the 7th and 14th days using H & E staining with Image J and SPSS softwares. Results: On 7th day, the smallest and highest wound surface was observed in the Scaffold and Control groups respectively (P

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