Rapid repair of skin ulcers in diabetic rats using polycaproplactone /gelatin nanon-fiber scaffold

authors:

avatar Fariba Zafari , avatar Morteza Sadeghi , avatar Mehrdad Bakhtiyari , avatar shahram teimourian , *

Koomesh: Vol.21, issue 3; 535-539
published online: October 01, 2019
article type: Research Article
received: January 02, 2018
accepted: October 01, 2018

how to cite: Zafari F, Sadeghi M, Bakhtiyari M, teimourian S. Rapid repair of skin ulcers in diabetic rats using polycaproplactone /gelatin nanon-fiber scaffold. koomesh. 2019;21(3):e153113. 

Abstract

Introduction: Three-dimensional nano scaffolds by creating a three-dimensional structure similar to the body tissues have created a new perspective on cell culture and tissue repair. The aim of this study was to investigate the effect of polycaprolactone biodegradation scaffold (PCL) in treatment of diabetic wounds. Materials and Methods: Nano PCL-Gelatine scaffold was synthesized by electrospun method. A circular wound (6 mm) was created in skin of 15 BALB/c rats and the rats were divided into 3 groups including: Non-diabetic group (sham), Diabetic group without nano scaffold receiving (control) and diabetic group with nano scaffolds (scaffold). Wound surface area and wound healing were evaluated on the 7th and 14th days using H & E staining with Image J and SPSS softwares. Results: On 7th day, the smallest and highest wound surface was observed in the Scaffold and Control groups respectively (P

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