Protective role of vitamin-D on chronic stress induced-learning and memory deficits in rats

authors:

avatar Sara Choobdar , avatar Abbas-Ali Vafaei , avatar A. li Rashidy-Pour , avatar Katayoun Sedaghat ORCID , *

Koomesh: Vol.21, issue 4; 708-715
published online: December 03, 2019
article type: Research Article
received: October 01, 2018
accepted: April 03, 2019

how to cite: Choobdar S, Vafaei A, Rashidy-Pour A L, Sedaghat K . Protective role of vitamin-D on chronic stress induced-learning and memory deficits in rats. koomesh. 2019;21(4):e153136. 

Abstract

Introduction: Long-term stress disturbs HPA axis and increases glucocorticoids release, which disturbs neural plasticity in the hippocampus and may lead to learning and memory deficits. Noticeably, vitamin D plays a protective role in the nervous system and has receptors in the hippocampus. This behavioral study investigates the possible protective role of vitamin-D against the negative effects of chronic stress on learning and memory. Materials and Methods: All the Rats were randomly divided to two groups stress and control groups (each had 3 subgroups). Stress-group animals were exposed to restraint stress for 28 days, 3 hours/day. During 28 days, vitamin D (5 or 10 mg/kg), or vehicle was injected (IP) twice weekly to both groups. At day 29, blood sample collected for serum corticosterone assay. Morris water maze (MWM) test was performed in the order of 4 days training, one-day probe testing and finally working memory test. Passive avoidance test was performed after MWM. Results: Stress group revealed higher levels of serum corticosterone (P

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