Effect of Nigella sativa seeds on the severity of symptoms of premenstrual syndrome: A randomized clinical trial

authors:

avatar maskani maskani , * , avatar Mahin Tafazoli , avatar Hasan Rakhshandeh , avatar Habibollah Esmaily

Koomesh: Vol.22, issue 1; 33-40
published online: August 03, 2020
article type: Research Article
received: December 02, 2018
accepted: August 03, 2019

How To Cite maskani M, Tafazoli M, Rakhshandeh H, Esmaily H. Effect of Nigella sativa seeds on the severity of symptoms of premenstrual syndrome: A randomized clinical trial. koomesh. 2020;22(1):e153146. 

Abstract

Introduction: Premenstrual syndrome refers to the presence of cyclic behavioral and physical symptoms that affects some women. Finding an effective and safe way to treat premenstrual syndrome has always been a serious concern. More than 95% of the young and middle-aged women are affected, and in 2-10% are severe enough to affect their lifestyle and occupation. The aim of this study was to determine the effect of Nigella sativa seeds on the severity of symptoms of premenstrual syndrome. Materials and Methods: This double blind randomized clinical trial study, performed on 84 students with symptoms of premenstrual syndrome residing in girls;#39 dormitories in Mashhad (Iran) University of Medical Sciences in 2017. They were randomly divided into two groups of case and control. Data collection tool was COPE form. Correspondingly, the severity of the symptoms was compared one and two months after the intervention by before intervention and the control group. The intervention group recived oral capsule containing 500 mg of Nigella sativa seeds and the control group received placebo capsule, three times a day from 7 days before the onset of menstrual bleeding to the first 3 days of menstrual bleeding for 2 cycles. Results: The overall severity of premenstrual syndrome symptoms had a significant reduction in the intervention group than the control group at the end of the first and second months after using Nigella sativa seeds Capsule(P

References

  • 1.

    Cmara RD, Khler CA, Frey BN, Hyphantis TN, Carvalho AF. Validation of the Brazilian portuguese version of the premenstrual symptoms screening Tool (PSST) and association of PSST scores with health-related quality of life. Braz J Psychiatry 2017; 39: 140-146.

  • 2.

    Marc A, Speroff L. Clinical gynecologic endocrinilogy and infertility. 8th ed. USA: Williams Wilkins; c2011, part 1, 567-578.

  • 3.

    Zarei Z, Bazzazian S. The relationship between premenstrual syndrome disorder, stress and quality of life in female students. Iran J Psychiat Nurs 2015; 2: 49-58. (Persian).

  • 4.

    Masoumi SZ, Ataollahi M, Oshvandi K. Effect of combined use of calcium and vitamin B6 on premenstrual syndrome symptoms: a randomized clinical trial. J Caring Sci 2016; 5: 67-73.

  • 5.

    Takeda T, Tasaka K, Sakata M, Murata Y. Prevalence of premenstrual syndrome and premenstrual dysphoric disorder in Japanese women. Arch Womens Ment Health 2006; 9: 209-212.

  • 6.

    Borenstein J, Chiou CF, Dean B, Wong J, Wade S. Estimating direct and indirect costs of premenopausal syndrome. J Occup Environ 2005; 47: 26-33.

  • 7.

    Shakeri Z. The relationship of lifestyle and attachmentstyle with premenstrual syndrome in Mashhad medical university student 2013. [dissertation]. Mashhad Univ Med Sci 1392; 10. (Persian).

  • 8.

    Milewicz A, Jedrzejuk D. Premenstrual syndrome: from etiology to treatment. Maturitas 2006; 55: S47-54.

  • 9.

    Siahbazi S, Behboudi-Gandevani S, Moghaddam-Banaem L, Montazeri A. Effect of zinc sulfate supplementation on premenstrual syndrome and healthrelated quality of life: Clinical randomized controlled trial. J Obstet Gynaecol Res 2017; 43: 887-894.

  • 10.

    Rosenfeld R, Livne D, Nevo O, Dayan L, Milloul V, Lavi S, Jacob G. Hormonal and volume dysregulation in women with premenstrual syndrome. Hypertension 2008; 51: 1225-1230.

  • 11.

    Verma RK CD, Pandey AK. Review on treatment of premenstrual syndrome: from conventional to alternative approach. J Basic Clin Physiol Pharmaco 2014; 25: 319-327.

  • 12.

    Levin AM. Pre-menstrual syndrome: a new concept in its pathogenesis and treatment. Med Hypotheses 2004; 36: 130-132.

  • 13.

    Steege JF, Blumenthal JA. Effects of aerobic exercise on premenstrual symptoms in middle-aged women: a preliminary study. J Psychosom Res 1993; 37: 127-123.

  • 14.

    Fallah H, Mohtashami R. A review of the pharmacological effects of Nigella sativa. J Med Plants 1390; 10: 1-14. (Persian).

  • 15.

    Bin Sayeed MS, Shams T, Fahim Hossain S, Rahman MR, Mostofa A, Fahim Kadir M, et al. Seeds modulate mood, anxiety and cognition in healthy adolescent males. J Ethnopharmacol 2014; 152: 156-162.

  • 16.

    Parhizkarsup S, Latiffsup LA, Rahmansup SA, Dollahsup MA, Parichehr H. Assessing estrogenic activity of Nigella sativa in ovariectomized rats using vaginal cornification assay. African J Pharmacy Pharmacol 2011; 5: 137-142.

  • 17.

    Valizadeh NA, Zakeri HR, Shafiee A, Sarkheil P, Heshmat RA, Larijani B. The effect of nigella sativa extract on biochemical bone markers in osteopenic postmenopausal women. Iran J Endocrinol Metab 2009; 10: 571-580.

  • 18.

    Mehnazadeh Falahieh F. Comparison of the effects of Nigella sativa and Mefenamic acid on primary dysmenorrhea. [dissertation]. Mashhad Univ Med Sci 1394. (Persian).

  • 19.

    Mohammad Azam. Great elixir, Volume 3: 658-697.

  • 20.

    Haywood A, Slade P, King H. Assessing the assessment measures for menstrual cycle symptoms: a guide for researchers and clinicians. J Psychosom Res 2002; 52: 223-237.

  • 21.

    C JE. modern management of Premenstrual syndrome. Women mental health. 2005;7(4).

  • 22.

    Ali BH, Blunden G, Tanira MO, Nemmar A. Some phytochemical, pharmacological and toxicological properties of ginger (Zingiber officinale Roscoe): a review of recent research. Food Chem Toxicol 2008; 46: 409-420.

  • 23.

    Girman A, Lee R, Kligler B. An integrative medicine approach to premenstrual syndrome. Am J Obstet Gynecol 2003; 188: S56-65.

  • 24.

    Aqel M, Shaheen R. Effects of the volatile oil of Nigella sativa seeds on the uterine smooth muscle of rat and guinea pig. J Ethnopharmacol 1996; 52: 23-26.

  • 25.

    Al-Ghamdi MS. The anti-inflammatory, analgesic and antipyretic activity of Nigella sativa. J Ethnopharmacol 2001; 76: 45-48.

  • 26.

    Tamadonfard Z, Sepehrara L, Johari H. The effect of nigella sativa extract on learning and spatial memory of adult male rats. J Jahrom Univ Med Sci 2014; 12: 27-36. (Persian).

  • 27.

    Rahman M, Yang DK, Kim GB, Lee SJ, Kim SJ. Nigella sativa seed extract attenuates the fatigue induced by exhaustive swimming in rats. Biomed Rep 2017; 6: 468-474.

  • 28.

    Fathizadeh S, Amani R, Haghighizadeh MH, Hormozi R. Comparison of serum zinc concentrations and body antioxidant status between young women with premenstrual syndrome and normal controls: A case-control study. Int J Reprod Biomed (Yazd) 2016; 14: 699-704. (Persian).

  • 29.

    Tofighiyan T, Kooshki A, Rakhshani MH. The effects of omega-3 fatty acids on premenstrual syndrome. Iran J Obstet Gynecol Infert 2013; 15: 23-28.

  • 30.

    Collins A, Cerin A, Coleman G, Landgren BM. Essential fatty acids in the treatment of premenstrual syndrome. Obstet Gynecol 1993; 81: 93-98.

  • 31.

    Shah Hosseini Z, Danesh MM, Amin GH, SalehiSormaghi MH, Abedian K. Double blind study of anti-primary dysmenorrhea effects of Vitagnus. J Mazendaran Univ Med Sci 2005; 16: 15-21. (Persian).##.