Effects of hydroalchoholic extract of Iranian Propolis on acute, chronic and visceral pain in mice

authors:

avatar Abbasali Taherian , * , avatar Hamid Reza Sameni , avatar Shima Sharifi , avatar Mohammad Hossein Taherian

Koomesh: Vol.22, issue 1; 170-177
published online: March 03, 2020
article type: Research Article
received: October 02, 2018
accepted: July 03, 2019

How To Cite Taherian A, Sameni H R, Sharifi S, Taherian M H. Effects of hydroalchoholic extract of Iranian Propolis on acute, chronic and visceral pain in mice. koomesh. 2020;22(1):e153164. 

Abstract

Introduction: Propolis is a natural bee product, which has been used in folk medicine for the management of different diseases. Regarding to anti-inflammatory effects of Propolis, in this study we evaluated the analgesic effects of hydroalchoholic extract of Iranian Propolis on acute and chronic pain. Materials and Methods: 192 young adult male albino mice (25-30 g) in 24 groups (n = 8) were used. Propolis (100, 200, and 500 mg/kg), vehicle and morphine as Positive control drug (5mg/Kg) were injected intera- peritoneally 30 min before the pain evaluation tests. Acute and chronic pain was assessed by by using hot plate (HP), tail flick (TF), formalin (FT) and writhing (WR) tests.  Results: Comapred to the control group, Propolis extract in all doeses increased pain tolerance in both the HP and TF (P

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