Efect of a controlled diet program on behavioral-emotional disorders in patients with phenylketonuria

Javad Shahpouri; Saeideh Karami; Seyed Mohammadi; Mohsen Mollamohammadi; Abolfazl Mohammadbeigi

Koomesh

Journal of Semnan University of Medical Sciences

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Efect of a controlled diet program on behavioral-emotional disorders in patients with phenylketonuria

Author(s):

Javad Shahpouri,

Saeideh Karami,

Seyed Mohammadi,

Mohsen Mollamohammadi,

Abolfazl Mohammadbeigi

^,*

Koomesh:Vol. 22, issue 2; 317-324

Published online:Sep 01, 2020

Article type:Research Article

Received:Jan 03, 2019

Accepted:May 01, 2019

How to Cite:Javad ShahpouriSaeideh KaramiSeyed MohammadiMohsen MollamohammadiAbolfazl MohammadbeigiEfect of a controlled diet program on behavioral-emotional disorders in patients with phenylketonuria.koomesh.22(2):e153184.

Abstract

Introduction: Phenylketonuria is a disorder due to deficiency of the phenylalanine hydroxylase enzyme. Delay or untreatement would cause impacts on motor-cognitive and individual-social skills. This study aimed to investigate the effect of a controlled diet program on behavioral-emotional disorders in patients with phenylketonuria. Materials and Methods: In a quasi-experimental study, 60 patients with phenylketonuria referred to Hazrate Masoumeh Hospital in Qom (the seventh largest city in Iran) were studied. The data were collected using parents;#39 strengths and difficulties questionnaire (SDQ) to assess the status of behavioral-emotional disorders in patients by one of parents. Data were collected before and after - a three-months controlled diet- intervention. Results: The mean of phenylalanine in the patients was 12.81 ± 5.89 mg/dl before intervention and was decreased to 11.88 ± 6.8 mg/dl after intervention and this difference was statistically significant (p=0.018). The most significant effect of intervention was on increase of prosocial behaviors equal to 45%, reduction of conduct problems 38.3%, reduction of hyperactivity-attention deficit problems by 35%, decrease of emotional symptoms by 35% (p

Keywords

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