A comparative study on the effects of fluoxetine and tamoxifen on the treatment of mastalgia: A randomized clinical trial

authors:

avatar Masoumeh Taghizadeh , avatar Ismail Elahabadi , avatar Zahra Kamiab ORCID , avatar Mohammad Reza Mohammadi Hassan , avatar Maryam Mortazavi Lahijani , avatar reza vazirinejad , avatar Amir Moghadam-Ahmadi ORCID , *

Koomesh: Vol.22, issue 4; 574-580
published online: December 01, 2020
article type: Research Article
received: July 02, 2019
accepted: May 01, 2020

how to cite: Taghizadeh M, Elahabadi I, Kamiab Z, Mohammadi Hassan M R , Mortazavi Lahijani M, et al. A comparative study on the effects of fluoxetine and tamoxifen on the treatment of mastalgia: A randomized clinical trial. koomesh. 2020;22(4):e153216. 

Abstract

Introduction: Mastalgia is a common complaint among women that requires proper medical treatment. The aim of this study was to investigate the comparison of fluoxetine versus tamoxifen  effects on the mastalgia. Materials and Methods: In this clinical trial, 62 women, who referred to surgical clinic of Rafsanjan Ali-Ibn Abi-Talib hospital in 2017, with a complaint of breast pain were selected and treated with fluoxetine or tamoxifen. Correspondingly, informed consent, demographic checklists and the visual scale of the pain were completed in pre-treatment and then 4, 8 and 12 weeks after the treatment. Results: There was no significant difference between two groups in body mass index, duration of illness and duration of pain (P>0.05). Both fluoxetine and tamoxifen significantly reduced pain (P0.05). Conclusion: Both fluoxetine and tamoxifen were equally effective as alternative therapies against mastalgia

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