Comparing the effect of metoclopramide and promethazine on preventing nausea and vomiting after laparoscopic cholecystectomy: A double-blind clinical trial

Mehrdad  Malekshoar; Hashem Jarineshin; Navid Kalani; Majid Vatankhah

Koomesh

Journal of Semnan University of Medical Sciences

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Comparing the effect of metoclopramide and promethazine on preventing nausea and vomiting after laparoscopic cholecystectomy: A double-blind clinical trial

Author(s):

Mehrdad Malekshoar

,

Hashem Jarineshin

,

Navid Kalani

,

Majid Vatankhah

^,*

Koomesh:Vol. 23, issue 2; 203-210

Published online:Jun 07, 2021

Article type:Research Article

Received:Jan 03, 2020

Accepted:Oct 07, 2020

How to Cite:Mehrdad Malekshoar Hashem JarineshinNavid KalaniMajid VatankhahComparing the effect of metoclopramide and promethazine on preventing nausea and vomiting after laparoscopic cholecystectomy: A double-blind clinical trial.koomesh.23(2):e153257.

Abstract

Introduction: Nausea and vomiting are conditions that could occur after anesthesia and lead to reduced activity and surgery dissatisfaction. Therefore, according to its importance, this study was accomplished in order to compere the effect of metoclopramide and promethazine on preventing nausea and vomiting after laparoscopic cholecystectomy. Materials and Methods: This study was a double-blind clinical trial of 60 ASA class I and II patients aged 18-70 who visited for elective laparoscopic cholecystectomy surgery. Patients were randomly divided into two groups, namely metoclopramide 10mg and promethazine 1mg/kg. The occurrence and intensity of nausea and vomiting, the hemodynamic parameters of patients before induction and one minute, 5 minutes, and 15 minutes after induction, and recovery at moment zero and after 30 minutes, one hour, and 2 hours were measured and recorded. Results: Hemodynamic parameters including heart rate (HR) and mean arterial pressure (MAP) were compared for the two groups in different times. Although no significant difference was observed in MAP analysis before recovery, the difference between the two groups during recovery was statistically significant (P>0.05). In HR analysis, the difference between different times was not statistically significant (P

Keywords

Laparoscopic Cholecystectomy.

کله سیستکتومی لاپاراسکوپی

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