Comparing the effect of metoclopramide and promethazine on preventing nausea and vomiting after laparoscopic cholecystectomy: A double-blind clinical trial

authors:

avatar Mehrdad Malekshoar ORCID , avatar Hashem Jarineshin ORCID , avatar Navid Kalani ORCID , avatar Majid Vatankhah ORCID , *

Koomesh: Vol.23, issue 2; 203-210
published online: June 07, 2021
article type: issue_documents_importer
received: January 03, 2020
accepted: October 07, 2020

how to cite: Malekshoar M , Jarineshin H, Kalani N, Vatankhah M. Comparing the effect of metoclopramide and promethazine on preventing nausea and vomiting after laparoscopic cholecystectomy: A double-blind clinical trial. koomesh. 2021;23(2):e153257. 

Abstract

Introduction: Nausea and vomiting are conditions that could occur after anesthesia and lead to reduced activity and surgery dissatisfaction. Therefore, according to its importance, this study was accomplished in order to compere the effect of metoclopramide and promethazine on preventing nausea and vomiting after laparoscopic cholecystectomy. Materials and Methods: This study was a double-blind clinical trial of 60 ASA class I and II patients aged 18-70 who visited for elective laparoscopic cholecystectomy surgery. Patients were randomly divided into two groups, namely metoclopramide 10mg and promethazine 1mg/kg. The occurrence and intensity of nausea and vomiting, the hemodynamic parameters of patients before induction and one minute, 5 minutes, and 15 minutes after induction, and recovery at moment zero and after 30 minutes, one hour, and 2 hours were measured and recorded. Results: Hemodynamic parameters including heart rate (HR) and mean arterial pressure (MAP) were compared for the two groups in different times. Although no significant difference was observed in MAP analysis before recovery, the difference between the two groups during recovery was statistically significant (P>0.05). In HR analysis, the difference between different times was not statistically significant (P

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