Comparing the effect of metoclopramide and promethazine on preventing nausea and vomiting after laparoscopic cholecystectomy: A double-blind clinical trial

authors:

avatar Mehrdad Malekshoar ORCID , avatar Hashem Jarineshin ORCID , avatar Navid Kalani ORCID , avatar Majid Vatankhah ORCID , *

Koomesh: Vol.23, issue 2; 203-210
published online: June 07, 2021
article type: Research Article
received: January 03, 2020
accepted: October 07, 2020

how to cite: Malekshoar M , Jarineshin H, Kalani N, Vatankhah M. Comparing the effect of metoclopramide and promethazine on preventing nausea and vomiting after laparoscopic cholecystectomy: A double-blind clinical trial. koomesh. 2021;23(2):e153257. 

Abstract

Introduction: Nausea and vomiting are conditions that could occur after anesthesia and lead to reduced activity and surgery dissatisfaction. Therefore, according to its importance, this study was accomplished in order to compere the effect of metoclopramide and promethazine on preventing nausea and vomiting after laparoscopic cholecystectomy. Materials and Methods: This study was a double-blind clinical trial of 60 ASA class I and II patients aged 18-70 who visited for elective laparoscopic cholecystectomy surgery. Patients were randomly divided into two groups, namely metoclopramide 10mg and promethazine 1mg/kg. The occurrence and intensity of nausea and vomiting, the hemodynamic parameters of patients before induction and one minute, 5 minutes, and 15 minutes after induction, and recovery at moment zero and after 30 minutes, one hour, and 2 hours were measured and recorded. Results: Hemodynamic parameters including heart rate (HR) and mean arterial pressure (MAP) were compared for the two groups in different times. Although no significant difference was observed in MAP analysis before recovery, the difference between the two groups during recovery was statistically significant (P>0.05). In HR analysis, the difference between different times was not statistically significant (P

References

  • 1.

    Watcha MF, White PF. Postoperative nausea and vomiting. Its etiology, treatment, and prevention. Anesthesiology 1992; 77: 162-184.

  • 2.

    Mortazavi Y, Alijanpour E, Rabei O, Babatabar H, Nasiri E. The combination effect of dexamethasone with either metoclopramide or propofol on nusea and vomiting afther general anesthesia. J Gorgan Univ Med Sci 2009; 11: 23-27. (Persian).

  • 3.

    Wilhem sm, Dehoome - Smith ML, Kale - Pradhan PB. Prevention of postoperative nausea and vomiting. Ann Pharmacother 2007; 41: 68-78.

  • 4.

    Pushplata Gupta, shilpijain. Postoperative nausea and vomiting prophylaxis: A comparative study of ondansetron, granisetron and granisetron and dexamethasone combination after modified radical mastectomy. Saudi J Anaesth 2014; 8: S67-71.

  • 5.

    Entezariasl M, Isazadehfar K, Noorani Z. The comparison effect of preoperative ondansetron and metoclopramide in reducing nausea and vomitting after loparoscopic cholecystectomy. J Ardabil Univ Med Sci 2013; 13: 155-163. (Persian).

  • 6.

    Davoudi M, Khoshraftar E. Comparison between promethazine and placebo in reducing post-operative nausea and vomiting after general anesthesia for cesarean section. Avicenna J Clin Med 2006; 12: 45-48.

  • 7.

    Talebpour M, Ghiasnejad Omrani N, Imani F, Shariat Moharari R, Pourfakhr P, et al. Comparison effect of promethazine/dexamethasone and metoclopramide /dexamethasone on postoperative nausea and vomiting after laparascopic gastric placation: a randomized clinical trial. Anesth Pain Med 2017; 7: e57810.

  • 8.

    Pardo Jr. MC, Miller RD. Basic of anesthesia, 7th Ed. 2018; p687-689.

  • 9.

    Rasouli M, Teymouri F. Complete Iranian generic refrences with nursing practices (5th edition). Tehran: Andisheh Rafih Pub 2011. (Persian).

  • 10.

    Harialchi K, Olangian Tehrani A. Comparison of metoclopramide, droperidol and promethazine for prophylaxis of nausea after outpatient surgeries. J Guilan Uni Med Sci 2005; 13: 60-64. (Persian).

  • 11.

    Alijanpour E, Mortazavi Y, Ale RH. Comparison of the effect of metoclopramide and droperidol associated with dexamethasone on nausea and vomiting after operation. Comparison of the effect of Metoclopramide and Droperidol associated with Dexamethasone on nausea and vomiting after operation. JBUMS 2006; 8: 32-35. (Persian).

  • 12.

    Sadeghi A, Mirkheshti A. Antiemetic effects of deroperidol compared with dexamethasone and metoclopramide in patients undergoing hysteroscopy: A randomized double - blinded clinical trial. Iran J Anesthesiol Crit Care 2016; 2: 51-58.##.

  • 13.

    Goodarzi M, Matar MM, Shafa M, Townsend JE, Gonzalez I. A prospective randomized blinded study of the effect of intravenous fluid therapy on post-operative nausea and vomiting in children undergoing strabismus surgery. Paediatr Anaesth 2006; 16: 49-53.