Effect of resistance training on general health, happiness and its correlation with glycemic control in diabetic men with peripheral neuropathy

authors:

avatar miri miri , * , avatar Farhad Gholami ORCID , avatar Mansoureh Mokaberian

Koomesh: Vol.23, issue 4; 433-440
published online: July 02, 2021
article type: Research Article
received: February 01, 2020
accepted: November 02, 2020

how to cite: miri M, Gholami F, Mokaberian M. Effect of resistance training on general health, happiness and its correlation with glycemic control in diabetic men with peripheral neuropathy. koomesh. 2021;23(4):e153271. 

Abstract

Introduction: Painful diabetic neuropathy may have psychological consequences and lower quality of life and happiness in this population. The aim of the present study was to investigate the effect of circuit resistance training on general health, happiness and its correlation with glucose control in diabetic men with peripheral neuropathy. Materials and Methods: In the present clinical trial study, 30 diabetic men with peripheral neuropathy were randomly divided into experimental (n=15) and control (n=15) groups based on the level of neuropathy. The experimental group performed a circuit resistance-training program (50%-60% of 1RM, 3 sessions a week) over 12 weeks. Before and 48 hours after the experimental period, body composition was measured and blood samples were collected in a fasting state. Furthermore, General Health Questionnaire (GHQ-28) and Oxford Happiness Inventory (OHI) assessed general health and happiness, respectively. Results: HbA1c level significantly decreased in the experimental group compared with the control group (P=0.04). In addition, general health and happiness significantly improved in the experimental group compared with the control group (P=0.0001 and P=0.001, respectively). Importantly, Pearson’s correlation also indicated a significant correlation between happiness with HbA1c (r=-0.4 and P=0.02) and general health with HbA1c (r=0.36 and P=0.04). Conclusion: Based on the results, diabetic patients with peripheral neuropathy may benefit from glucose-lowering effect of resistance training, which was coupled with improved general health score and happiness.

References

  • 1.

    Orlando G, Balducci S, Bazzucchi I, Pugliese G, Sacchetti M. Neuromuscular dysfunction in type 2 diabetes: underlying mechanisms and effect of resistance training. Diabetes Metab Res Rev 2016; 32: 40-50. https://doi.org/10.1002/dmrr.2658 PMid:25950170.

  • 2.

    Kluding PM, Pasnoor M, Singh R, Jernigan S, Farmer K, Rucker J, et al. The effect of exercise on neuropathic symptoms, nerve function, and cutaneous innervation in people with diabetic peripheral neuropathy. J Diabetes Complications 2012; 26: 424-429. https://doi.org/10.1016/j.jdiacomp.2012.05.007 PMid:22717465 PMCid:PMC3436981.

  • 3.

    Wu SC, Wrobel JS, Armstrong DG. Assessing the impact of pharmacologic intervention on the quality of life in diabetic peripheral neuropathic pain and fibromyalgia. Pain Med 2007; 8: 33-42. https://doi.org/10.1111/j.1526-4637.2007.00350.x PMid:17714114.

  • 4.

    Gore M, Brandenburg NA, Dukes E, Hoffman DL, Tai K-S, Stacey B. Pain severity in diabetic peripheral neuropathy is associated with patient functioning, symptom levels of anxiety and depression, and sleep. J Pain Symptom Manage 2005; 30: 374-385. https://doi.org/10.1016/j.jpainsymman.2005.04.009 PMid:16256902.

  • 5.

    Dixit S, Asiri F. Pharmacological and nonpharmacological therapies in the management of diabetic peripheral neuropathy in type 2 diabetes: a comprehensive review. J Cardiovasc Dis Res 2014; 5: 37-48. https://doi.org/10.5530/jcdr.2014.4.7.

  • 6.

    Sundaram M, Kavookjian J, Patrick JH, Miller LA, Madhavan SS, Scott VG. Quality of life, health status and clinical outcomes in Type 2 diabetes patients. Qual Life Res 2007; 16: 165-177. https://doi.org/10.1007/s11136-006-9105-0 https://doi.org/10.1007/s11136-006-9164-2 PMid:17033903.

  • 7.

    Siemionow M, Demir Y. Diabetic neuropathy: Pathogenesis and treatment. A review. J Reconstr Microsurg 2004; 20: 241-252. https://doi.org/10.1055/s-2004-823112 PMid:15088209.

  • 8.

    Pozzo MJ, Mociulsky J, Martinez ET, Senatore G, Farias JM, Sapetti A, et al. Diabetes and quality of life: initial approach to depression, physical activity, and sexual dysfunction. Am J Ther 2016; 23: 159-171. https://doi.org/10.1097/01.mjt.0000433949.24277.19 PMid:24858335.

  • 9.

    Balducci S, Iacobellis G, Parisi L, Di Biase N, Calandriello E, Leonetti F, et al. Exercise training can modify the natural history of diabetic peripheral neuropathy. J Diabetes Complications 2006; 20: 216-223. https://doi.org/10.1016/j.jdiacomp.2005.07.005 PMid:16798472.

  • 10.

    KhazaeePool M, Sadeghi R, Majlessi F, Rahimi Foroushani A. Effects of physical exercise programme on happiness among older people. J Psychiatr Ment Health Nurs 2015; 22: 47-57. https://doi.org/10.1111/jpm.12168 PMid:25492721.

  • 11.

    Dixit S, Maiya A, Shastry B. Effect of aerobic exercise on quality of life in population with diabetic peripheral neuropathy in type 2 diabetes: a single blind, randomized controlled trial. Qual Life Res 2014; 23: 1629-1640. https://doi.org/10.1007/s11136-013-0602-7 PMid:24326731.

  • 12.

    Abbaszaeh MS, Hosseini M, Rahnamania M, Abdolzadeh ghare aghaj SM. Relationship between anthropometric indices with physical activity, depression and blood pressure in the university students living in the dormitories. J Semnan Med Sci Univ 2019; 21: 759-767. (Persian).

  • 13.

    Moghtaderi A, Bakhshipour A, Rashidi H. Validation of Michigan neuropathy screening instrument for diabetic peripheral neuropathy. Clin Neurol Neurosurg 2006; 108: 477-481. https://doi.org/10.1016/j.clineuro.2005.08.003 PMid:16150538.

  • 14.

    Mokaberian M, Kashani V, Kashani K, Namdar Tajari S. The comparison of happiness in active and inactive old men and women in Tehran. J Dev Motor Learn 2014; 6: 183-194. (Persian).

  • 15.

    Tofighi A, Nozad J, Babaei S, Dastah S. The effect of aerobic training on general health index of inactive veterans. Iran J War Public Health 2013; 5: 40-45. (Persian).

  • 16.

    Alizadeh H, Jabbarzadeh S, Mahmoudi Z, Ara F. Comparative analysis of general health and life satisfaction among special and general wards. Iran J Nurs 2017; 30: 80-89. (Persian). https://doi.org/10.29252/ijn.30.105.80.

  • 17.

    Sardar M, Sohrabi M, Shamsian A, Aminzadeh R. Effects of aerobic exercise training on the mental and physical health and social functioning of patients with type 2 diabetes mellitus. Iran J Endocrinol Metab 2009; 11: 251-256. (Persian).

  • 18.

    Mohammad Rahimi Gh, Attarzadeh Hosseini SR. Effect of aerobic training and diet on insulin resistance and quality of life in type ii diabetic patients. Horizon Med Sci 2016; 22: 57-64. (Persian). https://doi.org/10.18869/acadpub.hms.22.1.57.

  • 19.

    Mousavi Gilani SR, Khazaei Feizabad A. The effects of aerobic exercise training on mental health and self-esteem of type 2 diabetes mellitus patients. Health Psychol Res 2019; 7: 10-14. https://doi.org/10.4081/hpr.2019.6576 PMid:30997432 PMCid:PMC6441819.

  • 20.

    Eshghbaz M, Arefi M, Noori A. The effect of an aerobic training course on happiness, social communication skills and life satisfaction in women. Woman Study Family 2014; 7: 69-92. (Persian).

  • 21.

    Church TS, Blair SN, Cocreham S, Johannsen N, Johnson W, Kramer K, et al. Effects of aerobic and resistance training on hemoglobin A1c levels in patients with type 2 diabetes: a randomized controlled trial. JAMA 2010; 304: 2253-2262. https://doi.org/10.1001/jama.2010.1710 PMid:21098771 PMCid:PMC3174102.

  • 22.

    Nazari M, Gholamrezaei S, Shabani R. Effect of a period circuit resistance training on components of the metabolic syndrome in females with Type 2 diabetes. Iran J Endocrinol Metab 2015; 17: 362-372. (Persian).

  • 23.

    Gholami F, Nikookheslat S, Salekzamani Y, Boule N, Jafari A. Effect of aerobic training on nerve conduction in men with type 2 diabetes and peripheral neuropathy: A randomized controlled trial. Neurophysiol Clin 2018; 48: 195-202. https://doi.org/10.1016/j.neucli.2018.03.001 PMid:29606547##.

  • 24.

    Dobretsov M, Hastings SL, Stimers J, Zhang JM. Mechanical hyperalgesia in rats with chronic perfusion of lumbar dorsal root ganglion with hyperglycemic solution. J Neurosci Methods 2001; 110: 9-15. https://doi.org/10.1016/S0165-0270(01)00410-1.

  • 25.

    Schreiber AK, Nones CF, Reis RC, Chichorro JG, Cunha JM. Diabetic neuropathic pain: physiopathology and treatment. World J Diabet 2015; 6: 432-444. https://doi.org/10.4239/wjd.v6.i3.432 PMid:25897354 PMCid:PMC4398900.

  • 26.

    Feldman EL, Nave KA, Jensen TS, Bennett DL. New horizons in diabetic neuropathy: mechanisms, bioenergetics, and pain. Neuron 2017; 93: 1296-1313. https://doi.org/10.1016/j.neuron.2017.02.005 PMid:28334605 PMCid:PMC5400015.

  • 27.

    Ghavami H, Ahmadi F, Mehin SH, Meamarian R, Entezami H. Assessment of the relation between diabetic neuropathy & HbA1C concentration. Razi J Med Sci 2007; 13: 141-147. (Persian).

  • 28.

    Yaribeygi H, Atkin SL, SimentalMenda LE, Sahebkar A. Molecular mechanisms by which aerobic exercise induces insulin sensitivity. J Cell Physiol 2019; 1-8. https://doi.org/10.1002/jcp.28066 PMid:30605232.

  • 29.

    Enteshary M, Esfarjani F, Reisi J. The comparison of 8 week combined training with two different intensity on level of serum Irisin, and glycemic indices of type 2 diabetic women. Med J Mashhad Univ Med Sci 2018; 61: 971-984. (Persian).

  • 30.

    Ali Zamani S, Ghasemi GhA, Karimi A, Salehi H. The effect of pilates exercises on pain and general health in patients with chronic low back pain. Res Rehab Sci 2011; 7: 117-125. (Persian).

  • 31.

    Miller DI, Taler V, Davidson PS, Messier C. Measuring the impact of exercise on cognitive aging: methodological issues. Neurobiol Agin 2012; 33: 62229-62243. https://doi.org/10.1016/j.neurobiolaging.2011.02.020 PMid:21514694.

  • 32.

    Esmaeili M, Bijeh N, Ghahremani Moghadam M. Effect of combined aerobic and resistance training on aerobic fitness, strength, beta-endorphin, blood glucose level, and insulin resistance in women with type 2 diabetes mellitus. Iran J Obstet Gynecol Infert 2018; 21: 34-46. (Persian).

  • 33.

    Nazar Ali P, Thiabi R, Hanachi P. Comparison of aerobic and anaerobic training on plasma endorphin levels in active and inactive girls. J Sport Biol Sci 2012; 13: 37-50. (Persian).