Antinociceptive and anti-inflammatory, and acute toxicity effects of Asparagus persicus essential oil in male mice

authors:

avatar Ali reza fallahzadeh , avatar saeed mohammadi , *

Koomesh: Vol.23, issue 4; 474-481
published online: August 03, 2021
article type: issue_documents_importer
received: July 09, 2020
accepted: January 03, 2021

how to cite: fallahzadeh A R, mohammadi S. Antinociceptive and anti-inflammatory, and acute toxicity effects of Asparagus persicus essential oil in male mice. koomesh. 2021;23(4):e153276. 

Abstract

Introduction: In Iranian traditional medicine, Asparagus persicus has been used for treating rheumatic pain and inflammation. The aim of this study was to evaluate the analgesic and anti-inflammatory as well as acute toxicity effects of Asparagus persicus root essential oil (APEO) in male mice. Materials and Methods: Male adult mice were used. In pain assessment tests (writhing, tail-flick, and formalin tests), animals divided to the six groups: control/vehicle (Tween 80+distilled water), three groups treated with the APEO (100, 200, and 400 mg/kg, gavage/oral treating), morphine (i.p.), and naloxone (i.p.) plus APEO (400 mg/kg). Moreover, inflammation test (xylene and carrageenan tests), animals divided to five groups: control, three groups of APEO (orally), and dexamethasone (i.p.). For toxicity tests, the animals were divided to the six groups. Results: Results showed that APEO at a dose of 400 mg/kg in writhing and tailflick tests induced an antinociceptive effect as compared with the control (P

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