Effect of fenofibrate on plasma level of BDNF and brain oxidative stress markers in pentylenetetrazole-induced kindling seizure in mice

authors:

avatar Nahid Sarahian , avatar Mohammad Taghi Mohammadi , * , avatar Shima Shahyad ORCID , avatar Mohsen Rezaei

Koomesh: Vol.23, issue 5; 636-645
article type: issue_documents_importer
received: January 01, 2021
accepted: April 02, 2021

how to cite: Sarahian N, Mohammadi M T, Shahyad S, Rezaei M. Effect of fenofibrate on plasma level of BDNF and brain oxidative stress markers in pentylenetetrazole-induced kindling seizure in mice. koomesh. 2021;23(5):e153296. 

Abstract

Introduction: The neuroprotective effect and pleiotropic functions of PPARα agonists (peroxisome proliferator activated receptor-alpha) such as fenofibrate and bezafibrate have been demonstrated by the previous studies. The current study evaluated the antiepileptic effects and neuroprotective functions of fenofibrate in pentylenetetrazole (PTZ)-induced kindling seizure in mice. Materials and Methods: Adult male NMRI mice were randomly assigned into three groups (n=8): Control, untreated kindled mice and fenofibrate-treated kindled animals. Repeated intraperitoneal injections of PTZ (45 mg/kg) once every 48 hours were used to develop the kindling seizure for 21 days. Treated mice were administered orally fenofibrate at doses of 30 mg/kg/day. Plasma level of brain-derived neurotrophic factor (BDNF), brain level of malondialdehyde (MDA) and histopathological changes were evaluated at termination of the study. Results: Fenofibrate administration considerably improved the seizure latency in treated kindled mice. Fenofibrate significantly (P

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