Significance of exosomes in COVID-19 pathogenesis and therapy

authors:

avatar Parviz Basiri , avatar Mohammad Hasan Soheilifar ORCID , * , avatar sima nobari , avatar Amir Hasan Nikfarjam , avatar Hoda Keshmiri Neghab ORCID , avatar Saeid Afshar ORCID , avatar Shima Ghorbanifar , avatar Ali Mahdavinezhad , **

Corresponding Authors:
Koomesh: Vol.23, issue 6; 673-682
published online: December 01, 2021
article type: Research Article
received: January 06, 2021
accepted: May 01, 2021

how to cite: Basiri P , Soheilifar M H, nobari S, Nikfarjam A H, Keshmiri Neghab H, et al. Significance of exosomes in COVID-19 pathogenesis and therapy. koomesh. 2021;23(6):e153300. 

Abstract

Exosomes are lipid bilayer-enclosed nano-sized vesicles, which carry various biomolecules including proteins, lipids, and microRNAs. SARS-CoV-2-loaded exosomes can be entered into the susceptible host cells, and transported viral components which are associated with viral particles intercellular transmission and spread of infection. Over-stimulation of the immune system followed by excessive proinflammatory cytokine production is a hallmark of COVID-19. Mesenchymal stem cell-derived exosomes are a potential therapeutic option in COVID-19 due to their ability to decrease cytokine storm, improve tissue regeneration, and prevent multi-organs failure. Unraveling the exact role of exosomes underlying COVID-19 infection will be beneficial in understanding novel aspects of COVID-19 pathogenesis and therapy. This study aimed to investigate the importance of exosomes in COVID-19

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