Effect of hormone receptors and Her-2 status on metastasis status in patients with breast cancer using logistic regression model

authors:

avatar Maedeh Raissi-zadeh , avatar Amal Saki Malehi ORCID , avatar Elham Maraghi ORCID , avatar Mahan Bahmanziari , * , avatar Mohammad Seghatoleslami , avatar Mehran Hosseinzadeh


how to cite: Raissi-zadeh M, Saki Malehi A, Maraghi E, Bahmanziari M, Seghatoleslami M, et al. Effect of hormone receptors and Her-2 status on metastasis status in patients with breast cancer using logistic regression model. koomesh. 2021;23(6):e153308. 

Abstract

Introduction: Breast cancer is the most common type of cancer and the leading cause of cancer death among women. According to estimates in 2018, the most frequency of cancer in Iranian women was related to breast cancer with 13776 (12.5%) new cases. Metastasis is a complication of this disease that occurs in 1%-5% of patients. The aim of this study was to investigate the effect of hormone receptors and Her-2 status on metastasis status in patients with breast cancer using logistic regression. Materials and Methods: In this retrospective study, medical records of 165 breast cancer patients referred to the Ahvaz Shafa Diagnostic and Treatment Center who underwent surgery during 2006-2014 was recorded. Multinomial logistic regression model was applied to identify the related factors to the metastasis status. Results: In the studied patients, 35.2% (58 patients) experienced metastasis. In multinomial logistic model, Her-2 status (P = 0.026) and lymph node involvement (P

References

  • 1.

    Raesizadeh M, Seghatoleslami M, Hoseinzade M, Saki Malehi A. Survival analysis of breast cancer patients according to intermediate and endpoint events: Applying illness-death model. Iran J of Epidemiol 2018; 13: 291-298 (Persian).

  • 2.

    W. H. Organization. WHO-CancerReport-2020-Global. World Health Organization 2020.

  • 3.

    W. H. Organization. WHO-CancerReport-2018-Global. World Health Organization 2018.

  • 4.

    W. H. Oganization. WHO-CancerReport-2018-Global. Iran, Islamic Republic of Source: Globcan 2018. World Health Organization 2019.

  • 5.

    Zendehdel K. Cancer statistics in IR Iran in 2018. Basic Clin Cancer Res 2019; 11: 1-4. https://doi.org/10.18502/bccr.v11i1.1645.

  • 6.

    Enayatrad M, Amoori N, Salehiniya H. Epidemiology and trends in breast cancer mortality in iran. Iran J Public Health 2015; 44: 430.

  • 7.

    Enayatrad M, Salehiniya H. An investigation of changing patterns in breast cancer incidence trends among Iranian women. J Sabzevar Univ Med Sci 2015; 22: 27-35. (Persian).

  • 8.

    Pareek A, Singh O, Yogi V, Ghori H, Tiwari V, Redhu P. Bone metastases incidence and its correlation with hormonal and human epidermal growth factor receptor 2 neu receptors in breast cancer. J Cancer Res Ther 2019; 15: 971. https://doi.org/10.4103/jcrt.JCRT_235_18 PMid:31603096.

  • 9.

    Yates LR, Knappskog S, Wedge D, Farmery JH, Gonzalez S, Martincorena I, et al. Genomic evolution of breast cancer metastasis and relapse. Cancer Cell 2017; 32: 169-184. https://doi.org/10.1016/j.ccell.2017.07.005 PMid:28810143 PMCid:PMC5559645.

  • 10.

    Ghavam Nasiri MR, Shahidsales S, Ahmadi-Simab S. Comparison of metastatic and non-metastatic breast cancer patients according to TNM, hormone status and Her-2 condition. Iran J Obstet Gynecol Infer 2014; 16: 1-5 (Persian).

  • 11.

    Gohari MR MZ AJ, Mohammadi M, Mokhtari P. Prognostic factors of metastasis in breast cancer patients using Anderson-Gill regression model. Koomesh 2013; 14: 483-489 (Persian).

  • 12.

    Mokarian F, Abdeyazdan N, Motamedi N, Tabesh P, Mokarian S, Hashemi F, et al. Risk factors of metastasis in women with breast cancer in Isfahan, Iran. J Isfahan Med School 2012; 29: 171 (Persian).

  • 13.

    Zhang ZP, Zhang XF, Li H, Liu TJ, Zhao QP, Huang LH, et al. Serum irisin associates with breast cancer to spinal metastasis. Medicine 2018; 97.

  • 14.

    Leone JP, Lee AV, Brufsky AM. Prognostic factors and survival of patients with brain metastasis from breast cancer who underwent craniotomy. Cancer Med 2015; 4: 989-994.

  • 15.

    Zhang W, Xu J, Wang K, Tang XJ, Liang H, He JJ. Independent risk factors for axillary lymph node metastasis in breast cancer patients with one or two positive sentinel lymph nodes. BMC Women's Health 2020; 20: 1-9.

  • 16.

    YektaKooshali M, Esmaeilpour BM, Sharami H, Alipour Z. Survival rate and average age of the patients with breast cancer in iran: systematic review and meta-analysis 2016; 18: 29-40 (Persian).

  • 17.

    Osmani F, Rasekhi A, Hajizadeh E, Akbari ME. Simultaneous modeling of multiple recurrences in breast cancer patients. Koomesh 2020; 22: 359-364 (Persian).##https://doi.org/10.29252/koomesh.22.2.359.

  • 18.

    Thakur P, Verma V, Dogra E, Gupta A, Gupta M, Fotedar V. Identification of breast cancer patients at risk for bone metastasis-A Case-Control Study. J Bone Soft Tissue Tumors Volume 2019; 5: 15-19.

  • 19.

    Khandani BK, Tavakkoli L, Khanjani N. Metastasis and its related factors in female breast cancer patients in Kerman, Iran. Asian Pacific J Cancer Prev 2017; 18: 1567-1571.

  • 20.

    Mendoza ES, Moreno E, Caguioa PB. Predictors of early distant metastasis in women with breast cancer. J Cancer Res Clin Oncol 2013; 139: 645-652.