Effects of methanolic extracts of Epilobium parviflorum on growth and function of human liver cells HepG2

authors:

avatar Elahe Roudsarabi , avatar Sakineh Kazemi , * , avatar Hassan Faridnouri , avatar Mohammad Reza Vaezi Kakhki ORCID

Koomesh: Vol.23, issue 6; 801-812
published online: December 03, 2021
article type: Research Article
received: January 01, 2021
accepted: May 03, 2021

how to cite: Roudsarabi E, Kazemi S, Faridnouri H, Vaezi Kakhki M R. Effects of methanolic extracts of Epilobium parviflorum on growth and function of human liver cells HepG2. koomesh. 2021;23(6):e153314. 

Abstract

Introduction: Epilobium parviflorum, the willow-herb, extracts contain strong antioxidant compounds and inhibit few types of cancer cell. This study investigates for the first time the effect of its extracts on the growth of human liver cells HepG2, also under oxidative stress. Materials and Methods: Methanolic extract of roots, shoots and flowers was prepared separately. Cell viability was assessed by MTT method after 48 hours of treatments with extracts and then with or without hydrogen peroxide treatment. The antioxidant capacity of the extracts as well as the activities of transaminases, superoxide dismutase and lipid peroxidase were measured in the treated cells. Results: None of the extracts showed cytotoxicty against HepG2 cells, nevertheless cell viability in treatment with aerial and root extracts was significantly increased (P

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