Logo

The Neuroprotective Effects of Astaxanthin on Anxiety-Like Behaviors and Oxidative Stress in the Cortex of Ethanol Model Mice

Author(s):
Akbar HajizadehAkbar HajizadehAkbar Hajizadeh ORCID1,*, Masoumeh Baradaran Paien RodposhtiMasoumeh Baradaran Paien RodposhtiMasoumeh Baradaran Paien Rodposhti ORCID1, Sedigheh KhanjaniSedigheh Khanjani1, Soroush Farhadi PahnedariSoroush Farhadi PahnedariSoroush Farhadi Pahnedari ORCID1
1Department of Animal Biology, Faculty of Basic Sciences, University of Mazandaran, Babolsar, Iran

Koomesh:Vol. 26, issue 6; e153385
Published online:Feb 24, 2025
Article type:Research Article
How to Cite:Hajizadeh A, Baradaran Paien Rodposhti M, Khanjani S, Farhadi Pahnedari S, The Neuroprotective Effects of Astaxanthin on Anxiety-Like Behaviors and Oxidative Stress in the Cortex of Ethanol Model Mice.koomesh.2025;26(6):e153385.https://doi.org/10.69107/koomesh-153385.

Abstract

References

  • 1.
    Coune F, Silvestre de Ferron B, Gonzalez-Marin MC, Antol J, Naassila M, Pierrefiche O. Resistance to ethanol sensitization is associated with a loss of synaptic plasticity in the hippocampus. Synapse. 2017;71(2). [PubMed ID:26898905]. https://doi.org/10.1002/syn.21899.
  • 2.
    Jeong J-s, Jeon H, Ko K-m, Chung B, Choi G-W. Production of anhydrous ethanol using various PSA (Pressure Swing Adsorption) processes in pilot plant. Renewable Energy. 2012;42:41-5. https://doi.org/10.1016/j.renene.2011.09.027.
  • 3.
    Patil S, Tawari S, Mundhada D, Nadeem S. Protective effect of berberine, an isoquinoline alkaloid ameliorates ethanol-induced oxidative stress and memory dysfunction in rats. Pharmacol Biochem Behav. 2015;136:13-20. [PubMed ID:26159088]. https://doi.org/10.1016/j.pbb.2015.07.001.
  • 4.
    Nishioka Y, Oyagi A, Tsuruma K, Shimazawa M, Ishibashi T, Hara H. The antianxiety-like effect of astaxanthin extracted from Paracoccus carotinifaciens. Biofactors. 2011;37(1):25-30. [PubMed ID:21328624]. https://doi.org/10.1002/biof.130.
  • 5.
    Jeanblanc J. Comorbidity Between Psychiatric Diseases and Alcohol Use Disorders: Impact of Adolescent Alcohol Consumption. Curr Addict Rep. 2015;2(4):293-301. https://doi.org/10.1007/s40429-015-0076-5.
  • 6.
    Crews FT, Vetreno RP, Broadwater MA, Robinson DL. Adolescent Alcohol Exposure Persistently Impacts Adult Neurobiology and Behavior. Pharmacol Rev. 2016;68(4):1074-109. [PubMed ID:27677720]. [PubMed Central ID:PMC5050442]. https://doi.org/10.1124/pr.115.012138.
  • 7.
    Mead EA, Sarkar DK. Fetal alcohol spectrum disorders and their transmission through genetic and epigenetic mechanisms. Front Genet. 2014;5:154. [PubMed ID:24917878]. [PubMed Central ID:PMC4040491]. https://doi.org/10.3389/fgene.2014.00154.
  • 8.
    Uban KA, Comeau WL, Ellis LA, Galea LA, Weinberg J. Basal regulation of HPA and dopamine systems is altered differentially in males and females by prenatal alcohol exposure and chronic variable stress. Psychoneuroendocrinology. 2013;38(10):1953-66. [PubMed ID:23579081]. [PubMed Central ID:PMC3758462]. https://doi.org/10.1016/j.psyneuen.2013.02.017.
  • 9.
    Ekpe L, Inaku K, Ekpe V. Antioxidant effects of astaxanthin in various diseases—a review. J Mol Pathophysiol. 2018;7(1). https://doi.org/10.5455/jmp.20180627120817.
  • 10.
    Wolf AM, Asoh S, Hiranuma H, Ohsawa I, Iio K, Satou A, et al. Astaxanthin protects mitochondrial redox state and functional integrity against oxidative stress. J Nutr Biochem. 2010;21(5):381-9. [PubMed ID:19423317]. https://doi.org/10.1016/j.jnutbio.2009.01.011.
  • 11.
    Komatsu T, Sasaki S, Manabe Y, Hirata T, Sugawara T. Preventive effect of dietary astaxanthin on UVA-induced skin photoaging in hairless mice. PLoS One. 2017;12(2):e0171178. [PubMed ID:28170435]. [PubMed Central ID:PMC5295690]. https://doi.org/10.1371/journal.pone.0171178.
  • 12.
    Manabe Y, Komatsu T, Seki S, Sugawara T. Dietary astaxanthin can accumulate in the brain of rats. Biosci Biotechnol Biochem. 2018;82(8):1433-6. [PubMed ID:29625535]. https://doi.org/10.1080/09168451.2018.1459467.
  • 13.
    Li J, Guo C, Wu J. Astaxanthin in Liver Health and Disease: A Potential Therapeutic Agent. Drug Des Devel Ther. 2020;14:2275-85. [PubMed ID:32606597]. [PubMed Central ID:PMC7293384]. https://doi.org/10.2147/DDDT.S230749.
  • 14.
    Braun AA, Skelton MR, Vorhees CV, Williams MT. Comparison of the elevated plus and elevated zero mazes in treated and untreated male Sprague-Dawley rats: effects of anxiolytic and anxiogenic agents. Pharmacol Biochem Behav. 2011;97(3):406-15. [PubMed ID:20869983]. [PubMed Central ID:PMC3006066]. https://doi.org/10.1016/j.pbb.2010.09.013.
  • 15.
    Seibenhener ML, Wooten MC. Use of the Open Field Maze to measure locomotor and anxiety-like behavior in mice. J Vis Exp. 2015(96):e52434. [PubMed ID:25742564]. [PubMed Central ID:PMC4354627]. https://doi.org/10.3791/52434.
  • 16.
    Bigdeli MR, Rasoulian B, Meratan AA. In vivo normobaric hyperoxia preconditioning induces different degrees of antioxidant enzymes activities in rat brain tissue. Eur J Pharmacol. 2009;611(1-3):22-9. [PubMed ID:19303405]. https://doi.org/10.1016/j.ejphar.2009.03.034.
  • 17.
    Kruger NJ. The Bradford Method For Protein Quantitation. In: Walker JM, editor. The Protein Protocols Handbook. Totowa, NJ: Humana Press; 2009. p. 17-24.
  • 18.
    Ksenofontov AL, Boyko AI, Mkrtchyan GV, Tashlitsky VN, Timofeeva AV, Graf AV, et al. Analysis of Free Amino Acids in Mammalian Brain Extracts. Biochemistry (Mosc). 2017;82(10):1183-92. [PubMed ID:29037139]. https://doi.org/10.1134/S000629791710011X.
  • 19.
    Hritcu L, Ciobica A. Intranigral lipopolysaccharide administration induced behavioral deficits and oxidative stress damage in laboratory rats: relevance for Parkinson's disease. Behav Brain Res. 2013;253:25-31. [PubMed ID:23850357]. https://doi.org/10.1016/j.bbr.2013.07.006.
  • 20.
    Habig WH, Jakoby WB. Glutathione S-transferases (rat and human). Methods Enzymol. 1981;77:218-31. [PubMed ID:6173570]. https://doi.org/10.1016/s0076-6879(81)77029-0.
  • 21.
    Yao H, Zhang D, Yu H, Shen H, Lan X, Liu H, et al. Chronic ethanol exposure induced anxiety-like behaviour by altering gut microbiota and GABA system. Addict Biol. 2022;27(5):e13203. [PubMed ID:36001417]. https://doi.org/10.1111/adb.13203.
  • 22.
    Facciol A, Marawi T, Syed E, Gerlai R. Age-dependent effects of embryonic ethanol exposure on anxiety-like behaviours in young zebrafish: A genotype comparison study. Pharmacol Biochem Behav. 2022;214:173342. [PubMed ID:35134449]. https://doi.org/10.1016/j.pbb.2022.173342.
  • 23.
    Varlinskaya EI, Hosova D, Towner T, Werner DF, Spear LP. Effects of chronic intermittent ethanol exposure during early and late adolescence on anxiety-like behaviors and behavioral flexibility in adulthood. Behav Brain Res. 2020;378:112292. [PubMed ID:31626849]. [PubMed Central ID:PMC7261490]. https://doi.org/10.1016/j.bbr.2019.112292.
  • 24.
    Kameda SR, Frussa-Filho R, Carvalho RC, Takatsu-Coleman AL, Ricardo VP, Patti CL, et al. Dissociation of the effects of ethanol on memory, anxiety, and motor behavior in mice tested in the plus-maze discriminative avoidance task. Psychopharmacology (Berl). 2007;192(1):39-48. [PubMed ID:17242924]. https://doi.org/10.1007/s00213-006-0684-9.
  • 25.
    Shoji H, Miyakawa T. Effects of test experience, closed-arm wall color, and illumination level on behavior and plasma corticosterone response in an elevated plus maze in male C57BL/6J mice: a challenge against conventional interpretation of the test. Mol Brain. 2021;14(1):34. [PubMed ID:33588907]. [PubMed Central ID:PMC7885464]. https://doi.org/10.1186/s13041-020-00721-2.
  • 26.
    Rodgers RJ, Johnson NJ, Cole JC, Dewar CV, Kidd GR, Kimpson PH. Plus-maze retest profile in mice: importance of initial stages of trail 1 and response to post-trail cholinergic receptor blockade. Pharmacol Biochem Behav. 1996;54(1):41-50. [PubMed ID:8728537]. https://doi.org/10.1016/0091-3057(95)02156-6.
  • 27.
    Viudez-Martinez A, Garcia-Gutierrez MS, Navarron CM, Morales-Calero MI, Navarrete F, Torres-Suarez AI, et al. Cannabidiol reduces ethanol consumption, motivation and relapse in mice. Addict Biol. 2018;23(1):154-64. [PubMed ID:28194850]. https://doi.org/10.1111/adb.12495.
  • 28.
    Lotosh NY, Kryuchkova AV, Kulikov EA, Kulikova IS, Selishcheva AA, Ogurtsov DP, et al. Effect of Nanoemulsions Containing Astaxanthin or Its Esters on the Spatial Behavior of 5XFAD Mice. Nanobiotechnol Rep. 2022;17(2):227-34. https://doi.org/10.1134/s2635167622020124.
  • 29.
    Gholami Roudmajani E, Hayati Roodbari N, Goudarzvand M, Parivar K. Protective Effect of Astaxanthin on Prenatal Bacterial Lipopolysaccharide Exposed Behavioral Deficits in Adult Mice. Iran Red Crescent Med J. 2020;22(2). https://doi.org/10.5812/ircmj.97600.
  • 30.
    Olufunmilayo EO, Gerke-Duncan MB, Holsinger RMD. Oxidative Stress and Antioxidants in Neurodegenerative Disorders. Antioxidants (Basel). 2023;12(2). [PubMed ID:36830075]. [PubMed Central ID:PMC9952099]. https://doi.org/10.3390/antiox12020517.
  • 31.
    Padovan JC, Dourado TMH, Pimenta GF, Bruder-Nascimento T, Tirapelli CR. Reactive Oxygen Species Are Central Mediators of Vascular Dysfunction and Hypertension Induced by Ethanol Consumption. Antioxidants (Basel). 2023;12(10). [PubMed ID:37891892]. [PubMed Central ID:PMC10604002]. https://doi.org/10.3390/antiox12101813.
  • 32.
    Shirazpour S, Sepehri G, Taheri F, Shahrokhi Raeini A, Zangiabadi M, Sheikhi S. [The effects of high-intensity interval training on oxidative stress indices in the hippocampus following ethanol consumption in male rats]. Koomesh 2023;25(5). Persian.
  • 33.
    Goc Z, Kapusta E, Formicki G, Martiniakova M, Omelka R. Effect of taurine on ethanol-induced oxidative stress in mouse liver and kidney. Chin J Physiol. 2019;62(4):148-56. [PubMed ID:31535630]. https://doi.org/10.4103/CJP.CJP_28_19.
  • 34.
    Shim SY, Kim HS. Oxidative stress and the antioxidant enzyme system in the developing brain. Korean J Pediatr. 2013;56(3):107-11. [PubMed ID:23559971]. [PubMed Central ID:PMC3611043]. https://doi.org/10.3345/kjp.2013.56.3.107.
  • 35.
    Ros-Simo C, Moscoso-Castro M, Ruiz-Medina J, Ros J, Valverde O. Memory impairment and hippocampus specific protein oxidation induced by ethanol intake and 3, 4-methylenedioxymethamphetamine (MDMA) in mice. J Neurochem. 2013;125(5):736-46. [PubMed ID:23521165]. https://doi.org/10.1111/jnc.12247.
  • 36.
    Lotfi A, Abroodi Z, Khazaei M. [Single and Synergic Effects of Gamma Aminobutyric Acid (GABA) and Astaxanthin on Type 1 Diabetes Induced by Streptozotocin in Rat]. Koomesh 2023;25(5). Persian.
  • 37.
    Gholami Roudmajani E, Goudarzvand M, Hayati Roodbari N, Parivar K. [Evaluation of the protective effect of astaxanthin against undesired effects of Prenatal bacterial lipopolysaccharide (LPS) exposure on maternal behaviors and neuronal changes in Adult Male Offspring in NMRI Mice]. Koomesh 2023;25(5). Persian.
  • 38.
    Taksima T, Chonpathompikunlert P, Sroyraya M, Hutamekalin P, Limpawattana M, Klaypradit W. Effects of Astaxanthin from Shrimp Shell on Oxidative Stress and Behavior in Animal Model of Alzheimer's Disease. Mar Drugs. 2019;17(11). [PubMed ID:31690015]. [PubMed Central ID:PMC6891431]. https://doi.org/10.3390/md17110628.
  • 39.
    Kuedo Z, Sangsuriyawong A, Klaypradit W, Tipmanee V, Chonpathompikunlert P. Effects of Astaxanthin from Litopenaeus Vannamei on Carrageenan-Induced Edema and Pain Behavior in Mice. Molecules. 2016;21(3):382. [PubMed ID:27007359]. [PubMed Central ID:PMC6272999]. https://doi.org/10.3390/molecules21030382.
  • 40.
    Liu X, Shibata T, Hisaka S, Osawa T. Astaxanthin inhibits reactive oxygen species-mediated cellular toxicity in dopaminergic SH-SY5Y cells via mitochondria-targeted protective mechanism. Brain Res. 2009;1254:18-27. [PubMed ID:19101523]. https://doi.org/10.1016/j.brainres.2008.11.076.
  • 41.
    Shen H, Kuo CC, Chou J, Delvolve A, Jackson SN, Post J, et al. Astaxanthin reduces ischemic brain injury in adult rats. FASEB J. 2009;23(6):1958-68. [PubMed ID:19218497]. [PubMed Central ID:PMC2698661]. https://doi.org/10.1096/fj.08-123281.
  • 42.
    Pereira CPM, Souza ACR, Vasconcelos AR, Prado PS, Name JJ. Antioxidant and anti‑inflammatory mechanisms of action of astaxanthin in cardiovascular diseases (Review). Int J Mol Med. 2021;47(1):37-48. [PubMed ID:33155666]. [PubMed Central ID:PMC7723678]. https://doi.org/10.3892/ijmm.2020.4783.
  • 43.
    Lin X, Bo H, Gu J, Yi X, Zhang P, Liu R, et al. Astaxanthin, a carotenoid antioxidant, pretreatment alleviates cognitive deficits in aircraft noised mice by attenuating inflammatory and oxidative damage to the gut, heart and hippocampus. Biomed Pharmacother. 2022;148:112777. [PubMed ID:35255410]. https://doi.org/10.1016/j.biopha.2022.112777.
  • 44.
    Kato T, Kasai T, Sato A, Ishiwata S, Yatsu S, Matsumoto H, et al. Effects of 3-Month Astaxanthin Supplementation on Cardiac Function in Heart Failure Patients with Left Ventricular Systolic Dysfunction-A Pilot Study. Nutrients. 2020;12(6). [PubMed ID:32604721]. [PubMed Central ID:PMC7353230]. https://doi.org/10.3390/nu12061896.
  • 45.
    Zuluaga M, Gueguen V, Letourneur D, Pavon-Djavid G. Astaxanthin-antioxidant impact on excessive Reactive Oxygen Species generation induced by ischemia and reperfusion injury. Chem Biol Interact. 2018;279:145-58. [PubMed ID:29179950]. https://doi.org/10.1016/j.cbi.2017.11.012.
comments

Leave a comment here


Crossmark
Crossmark
Checking
Share on
Cited by
Metrics

Purchasing Reprints

  • Copyright Clearance Center (CCC) handles bulk orders for article reprints for Brieflands. To place an order for reprints, please click here (   https://www.copyright.com/landing/reprintsinquiryform/ ). Clicking this link will bring you to a CCC request form where you can provide the details of your order. Once complete, please click the ‘Submit Request’ button and CCC’s Reprints Services team will generate a quote for your review.
Search Relations

Author(s):

Related Articles