Seroprevalence of Chlamydia pneumonia in patients with myocardial infarction

Introduction: Several predisposing and risk factors are introduced as main causes of coronary atherosclerosis which is the main cause of myocardial infarction (MI). In recent years, chronic and persistent infections are considered as such factors. This study is basically on determination of seropositivity to Chlamydia pneumonia to reveal the role of acute and chronic infections due to these bacteria as a risk factor for MI. Materials and Methods: 273 serum samples from MI patients and 109 samples from control group were examined by using commercial quantitative ELISA kits to measure specific anti chlamydia pneumonia antibodies (IgM and IgG). Two groups were matched for age and sex. Results: IgM titers (ELISA) were negative in all patients and control cases, indicating lack of acute Chlamydial infection, but IgG titers were positive in 273 patients (94.4%), (mean average titer: 108 RU/ml) and in 109 control cases (84.4%) (mean average of titer: 61.9 RU/ml). We found no significant relationship between seropositivity to chlamydia pneumonia antibodies (IgG) with MI (P=0.104). Conclusion: In this study, no significant relationship was observed between serpositivity to Chlamydia pneumonia and subsequent incidence of MI. It seems that a large scale serological study with a diagnostic molecular methods for detection of genome in biopsy tissue of atherosclerotic coronary artery will be more helpful to reveal the expected relationship