Frequency of colorectal cancer in healthy individual’s relatives: A cross-sectional population-based study

Azadeh Safaei; Bijan Moghimi-Dehkordi; Seyed Reza Fatemi; Mohammad Amin Porhosingholi; Mohsen Vahedi; Asma PorHoseingholi; Manijeh Habibi; Mohammad Reza Zali

Koomesh

Journal of Semnan University of Medical Sciences

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Frequency of colorectal cancer in healthy individual’s relatives: A cross-sectional population-based study

Author(s):

Azadeh Safaei,

Bijan Moghimi-Dehkordi^,*,

Seyed Reza Fatemi,

Mohammad Amin Porhosingholi,

Mohsen Vahedi,

Asma PorHoseingholi,

Manijeh Habibi,

Mohammad Reza Zali

Koomesh:Vol. 12, issue 2; 129-133

Published online:Sep 25, 2010

Article type:Research Article

Received:Jul 02, 2010

Accepted:Aug 24, 2010

How to Cite:Azadeh SafaeiBijan Moghimi-DehkordiSeyed Reza FatemiMohammad Amin PorhosingholiMohsen VahediAsma PorHoseingholiManijeh HabibiMohammad Reza Zaliet al.Frequency of colorectal cancer in healthy individual’s relatives: A cross-sectional population-based study.koomesh.12(2):e153809.

Abstract

Introduction: Family history of colorectal cancer has been shown to be related to the risk of developing colorectal cancer. This risk depends on the number of affected relatives and the age at diagnosis. In this study we aimed to estimate the frequency of a positive family history of colorectal cancer in a random sample from Tehran population. Materials and Methods: This study was a community-based cross-sectional survey conducted from May 2006 to December 2007 in Tehran province, Iran. A total of 5,500 peoples (age≥20 years) drawn up randomly by random sampling according to postal codes and invited to participate in the study. All participants completed a detailed health data registry form on family history status of colorectal cancer. Results: The mean age of men with a positive family history was significantly different from men with negative family history. There was no significant difference between mean age of women responders with or without positive family history. Among all participants (n=5,500), 162 responders (2.9%) had a history of colorectal cancer. Of 162, 67 responders (1.22%) had one and 4(0.07%) had two or more first-degree relative with colorectal cancer. Of 5,500 participants, 18 subjects (0.33%) reported having two or more first-degree relative with colorectal cancer or one first-degree relative with colorectal cancer diagnosed at age

Keywords

Colorectal cancer, Family history, Population-based study

سرطان روده بزرگ، سابقه فامیلی، مطالعه مبتنی جمعیت

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