Celiac disease in dyspeptic patients

Mohammad Rostami-Nejad; Hamid Mahbobipor; Zeynab Fazeli; Reza Mashayekhi; Daryosh MirSatari; Ehasn NazemolHoseini; Mojgan Forotan; Amir Hoshang AliZadeh; Faramarz derakhshan; Mohammad Reza Zali

Koomesh

Journal of Semnan University of Medical Sciences

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Celiac disease in dyspeptic patients

Author(s):

Mohammad Rostami-Nejad

^,*,

Hamid Mahbobipor,

Zeynab Fazeli,

Reza Mashayekhi,

Daryosh MirSatari,

Ehasn NazemolHoseini,

Mojgan Forotan,

Amir Hoshang AliZadeh,

Faramarz derakhshan,

Mohammad Reza Zali

Koomesh:Vol. 12, issue 2; 209-214

Published online:Feb 25, 2011

Article type:Research Article

Received:Aug 10, 2009

Accepted:Jul 03, 2010

How to Cite:Mohammad Rostami-NejadHamid MahbobiporZeynab FazeliReza MashayekhiDaryosh MirSatariEhasn NazemolHoseiniMojgan ForotanAmir Hoshang AliZadehFaramarz derakhshanMohammad Reza Zaliet al.Celiac disease in dyspeptic patients.koomesh.12(2):e153818.

Abstract

Introduction: The screening of patients with dyspepsia, may allow an early identification of affected individuals. The aim of this study was to determine the prevalence of celiac disease in dyspeptic patients submitted to routine diagnostic upper gastrointestinal endoscopy. Materials and Methods: From November 2007 to October 2008, 407 patients who underwent endoscopy for any reason (193 male, 214 women mean age36.1 years) were studied in this work. Histological characteristics in duodenal biopsy specimens for celiac disease were evaluated according to the modified Marsh Classification1999. In addition, all patients were tested for total immunoglobulin A and anti-transglutaminase (tTG) antibodies. The patients with IgA deficiency were tested with IgG tTG. Results: Duodenal histology showed the malabsorption pattern (Marsh I-IIIc) in 26 (6.4%) cases and 33 cases had serological positive test for tTGA. In term of the serological analysis, 10 out of 33 tTGA positive patients had malabsorption pattern (Marsh I,-IIIc), and all of them had a positive tTGA (2.45%). Four of the 407 recruited patients were IgA deficient and none of them were positive for IgG tTG. Conclusion: In this study, about 6.4% of patients had malabsorption pattern and 8.1 % presented with positive serology for CD. However, both histology and serology were positive in 10/407 (2.45%). The high prevalence of celiac among dyspeptic symptomatic individuals indicates that they are a higher risk group for developing celiac disease.

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