Effects of hydroalchoholic extract of Securigera securidaca L. seed on acute, chronic and visceral pain in male albino mice

Hamidreza Sameni; Majid Jadidi; Sajad Sadeghi; Shima Sharifi; Abbasali Taherian

doi:10.5812/koomesh-153901

Koomesh

Journal of Semnan University of Medical Sciences

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Effects of hydroalchoholic extract of Securigera securidaca L. seed on acute, chronic and visceral pain in male albino mice

Author(s):

Hamidreza Sameni¹,

Majid Jadidi²,

Sajad Sadeghi³,

Shima Sharifi³,

Abbasali Taherian^4,*

1Research Center of Nervous System Stem Cells, Dept. of Anatomical Sciences, School of Medicine, Semnan University of Medical sciences, Semnan, Iran

2- Research Center of Physiology and Department of Medical Physics, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran

3Student Research Committee, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran

4- laboratory of pain Research Center of Physiology, School of Medicine, Semnan University of Medical sciences, Semnan, Iran

Koomesh:Vol. 17, issue 2; e153901

Published online:Mar 21, 2016

Article type:Research Article

How to Cite:Hamidreza SameniMajid JadidiSajad SadeghiShima SharifiAbbasali TaherianEffects of hydroalchoholic extract of Securigera securidaca L. seed on acute, chronic and visceral pain in male albino mice.koomesh.17(2):e153901.

Abstract

Introduction: Studies have shown that Securigera securidaca L. seed (SS) has anti-epileptic, anti-diabetic, anti-hypertensive, hypokalemic, hypoglysemic, diuretic and anti-convulsion effects. The present study was designed to test the antinoceceptive effects of hydro alcoholic extract of SS seed on acute, chronic, and visceral pain in mice. Material and Methods: Young adult male albino mice (n =160) within the weight range of 25-30 g were randomly divided into 20 groups (n = 8). SS (100, 200, and 500 mg/kg) and vehicle (VEH) were administered (IP) 30 min before the pain evaluation tests. Acute and chronic pain was assessed by Hot Plate, Tail Flick, Formalin and Writhing (visceral pain) tests. Results: Results indicated that SS had analgesic effects (P < 0.05) in comparison to the control group and the highest dose was more effective (P < 0.001). Conclusion: The finding of this study showed that SS has inhibitory effects on pain in experimental animals

Keywords

Securigera securidaca

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