Effects of hydroalchoholic extract of Turmeric (Curcuma longa) Rhizome on the peripheral and visceral pain in mice

Majid Jadidi; Hamidreza Sameni; Zeynab mirbeygi; Maryam Jafari; Abbasali Taherian

doi:10.5812/koomesh-153908

Koomesh

Journal of Semnan University of Medical Sciences

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Effects of hydroalchoholic extract of Turmeric (Curcuma longa) Rhizome on the peripheral and visceral pain in mice

Author(s):

Majid Jadidi¹,

Hamidreza Sameni²,

Zeynab mirbeygi³,

Maryam Jafari⁴,

Abbasali Taherian^4,*

1Research Center of Physiology and Dept. of Medical Physics, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran

2Research Center of Nervous System Stem Cells, Dept. of Anatomical Sciences, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran

3Student research committee, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran

4Laboratory of Pain. Research Center of Physiology, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran

Koomesh:Vol. 17, issue 3; e153908

Published online:Aug 21, 2016

Article type:Research Article

How to Cite:Majid JadidiHamidreza SameniZeynab mirbeygiMaryam JafariAbbasali TaherianEffects of hydroalchoholic extract of Turmeric (Curcuma longa) Rhizome on the peripheral and visceral pain in mice.koomesh.17(3):e153908.

Abstract

Introduction: Previously it has been shown that Curcuma longa (CL) has anti-inflammatory, antioxidant, antiviral, antifungal, antitumor, and antiniceceptive activity in neuropathic injury, when it is administered systemically, although the mechanisms that mediate these effects are not clear. The aim of present study was to determine the peripheral and visceral antinoceceptive effects of hydroalchoholic extract of CL on peripheral and visceral neuropathic pain in mice. Materials and methods: This study was conducted using 160 young adult male albino mice (25-30 g.) in 20 groups (n=8). CL (100, 200, and 500 mg/Kg IP), vehicle (VEH), and (Saline) were injected interaperitonealy 30 min before the pain evaluation tests. Acute and chronic pains were assessed by host plate, tail flick and formaline tests models and visceral pain was assessed by writhing test. Results: Results indicated that CL has analgesic effects on neuropathic pain (p

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