Abstract
Introduction: Previously it has been shown that Curcuma longa (CL) has anti-inflammatory, antioxidant, antiviral, antifungal, antitumor, and antiniceceptive activity in neuropathic injury, when it is administered systemically, although the mechanisms that mediate these effects are not clear. The aim of present study was to determine the peripheral and visceral antinoceceptive effects of hydroalchoholic extract of CL on peripheral and visceral neuropathic pain in mice. Materials and methods: This study was conducted using 160 young adult male albino mice (25-30 g.) in 20 groups (n=8). CL (100, 200, and 500 mg/Kg IP), vehicle (VEH), and (Saline) were injected interaperitonealy 30 min before the pain evaluation tests. Acute and chronic pains were assessed by host plate, tail flick and formaline tests models and visceral pain was assessed by writhing test. Results: Results indicated that CL has analgesic effects on neuropathic pain (p
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Copyright
© 2016, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.