Treatment of vitamin D deficiency with high-dose vitamin D supplementation and its effect on hematological indices in pregnancy: A secondary analysis of a randomized clinical trial

Farahnaz Rostami; Lida Banaem; Navid Ghasemi; Sedigheh Hantoushzadeh

doi:10.5812/koomesh-154039

Koomesh

Journal of Semnan University of Medical Sciences

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Treatment of vitamin D deficiency with high-dose vitamin D supplementation and its effect on hematological indices in pregnancy: A secondary analysis of a randomized clinical trial

Author(s):

Farahnaz Rostami¹,

Lida Banaem²,

Navid Ghasemi³,

Sedigheh Hantoushzadeh

^4,*

1Dept. of Medical Sciences, Islamic Azad University, Tehran, medical sciences branch, Tehran, Iran

2Dept. of Midwifery & Reproductive Health, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran

3- Dept. of Medical science, Shahrood Branch, Islamic Azad University, Shahrood, Iran

4- Maternal, Fetal & Neonatal Research Center, Tehran University of Medical Sciences, Tehran, Iran

Koomesh:Vol. 22, issue 4; e154039

Published online:Dec 24, 2020

Article type:Research Article

How to Cite:Farahnaz RostamiLida BanaemNavid GhasemiSedigheh HantoushzadehTreatment of vitamin D deficiency with high-dose vitamin D supplementation and its effect on hematological indices in pregnancy: A secondary analysis of a randomized clinical trial.koomesh.22(4):e154039.

Abstract

Introduction: There are few studies regarding the treatment of vitamin D deficiency with a high dose of vitamin D and the comparison of serum vitamin D levels and hematological indices (Hemoglobin, Hematocrit, Platelet and Ferritin) in the first and second trimesters of pregnancy. The aim of this study was to evaluate the effect of vitamin D supplementation on these hematological indices in pregnant women with vitamin D deficiency. Materials and Methods: The present study was performed in October 2019 from a secondary and non-predetermined analysis of the effect of vitamin D supplementation and comparison of serum vitamin D levels on blood parameters from a randomized controlled clinical trial. 215 pregnant mothers with vitamin D deficiency were entered in the study and were divided into two treatment groups of 50,000 units and 1000 units. Results: Mean serum levels of Hematocrit, Platelets, and Ferritin after treatment in the treatment groups with 50000 and 1000 unites were 38.6± 3.03 vs 36.05± 2.8 (P

Keywords

Vitamin D

Vitamin D Deficiency

Pregnancy

Iron Deficiency Anemia

Hemoglobin

Ferritin

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