Effects of administration of dexmedetomidine with intrathecal bupivacaine on analgesia after femoral and tibia orthopedic surgery: A double-blind randomized clinical trial study

Ahmad Rastegarian; seyed ebrahim Sadeghi; Mohammad Hasan Damshenas; Masoud Ghanei; Navid Kalani; Homan Hemati; Mohammad Radmehr

doi:10.5812/koomesh-154040

Koomesh

Journal of Semnan University of Medical Sciences

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Effects of administration of dexmedetomidine with intrathecal bupivacaine on analgesia after femoral and tibia orthopedic surgery: A double-blind randomized clinical trial study

Author(s):

Ahmad Rastegarian¹,

seyed ebrahim Sadeghi²,

Mohammad Hasan Damshenas^1,*,

Masoud Ghanei¹,

Navid Kalani

^{1, 3},

Homan Hemati⁴,

Mohammad Radmehr⁵

1Critical care and pain management research center, Jahrom University of Medical Sciences, Jahrom, Iran

2– Dep t. of Anesthesiology, Shiraz University of Medical Sciences, Shiraz, Iran

3- Student research committee, Jahrom University of Medical Sciences, Jahrom, Iran

4Student research committee, Jahrom University of Medical Sciences, Jahrom, Iran

5- Critical care and pain management research center, Jahrom University of Medical Sciences, Jahrom, Iran

Koomesh:Vol. 22, issue 4; e154040

Published online:Dec 24, 2020

Article type:Research Article

How to Cite:Ahmad Rastegarianseyed ebrahim SadeghiMohammad Hasan DamshenasMasoud GhaneiNavid KalaniHoman HematiMohammad Radmehret al.Effects of administration of dexmedetomidine with intrathecal bupivacaine on analgesia after femoral and tibia orthopedic surgery: A double-blind randomized clinical trial study.koomesh.22(4):e154040.

Abstract

Introduction: Various drugs are used as adjuvants for various purposes such as increasing analgesia, reducing analgesic complications and generally improving the quality of anesthesia with topical anesthetics. The use of alpha-2 agonists has recently been considered. One of these drugs is dexmedetomidine, which has been studied recently. The aim of this study was to evaluate the effect of dexmedetomidine as an adjunct to bupivacaine in spinal anesthesia in femoral fracture orthopedic surgery. Materials and Methods: This double-blind randomized clinical trial study was performed on 60 patients 18-50 years old with Class I and II anesthesia who were candidates for tibia and femur orthopedic fracture surgery. Patients were randomly divided into two groups of intervention: 12.5 mg bupivacaine (2.5 cc) and 5 µg dexmedomidine (0.5 ml) and control group: 12.5 mg bupivacaine and 0.5 ml normal saline. Systolic, diastolic, and mean arterial blood pressure and pulse counts were recorded before spinal anesthesia, after anesthesia and then every 15 minutes until surgery and at recovery time. At 2, 8, 4, 12, and 24 hours postoperatively, patients were evaluated for pain, opioid administration during the first 24 hours, and the time of first analgesic administration. Results: There was a significant difference between the bupivacaine-normal saline and bupivacaine- dexmedetomidine groups in terms of systolic and diastolic blood pressure at 15, 30, 45 and 60 minutes during surgery (P

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